95745-38-3

Basic information

• Product Name: Urea, N,N'-bis([1,1'-biphenyl]-4-yl)-
• CAS NO: 95745-38-3
• Molecular Formula: C25H20N2O
• Molecular Weight: 364.447
• Mol File: 95745-38-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Urea, N,N'-bis([1,1'-biphenyl]-4-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Urea, N,N'-bis([1,1'-biphenyl]-4-yl)-(95745-38-3)
• EPA Substance Registry System: Urea, N,N'-bis([1,1'-biphenyl]-4-yl)-(95745-38-3)

Safety Data

• Hazardous Substances Data: 95745-38-3(Hazardous Substances Data)

Upstream product

• 32315-10-9 bis(trichloromethyl) carbonate 
• 92-67-1 4-phenylalanine 
• 3582-05-6 trifluoromethyl trifluoromethanesulfonate 
• 92-95-5 4-biphenyl isocyanate 
• 13262-48-1 N-(4-biphenylyl)urea 
• 871876-66-3 N-ethyl-N'-biphenyl-4-yl-urea 

Downstream Products

• 5326-53-4 1,2-di([1,1'-biphenyl]-4-yl)diazene 

Relevant articles and documents

Concise and Additive-Free Click Reactions between Amines and CF3SO3CF3

Trifluoromethyl trifluoromethanesulfonate has proved to be an excellent reservoir of difluorophosgene and a promising click ligation for amines in the preparation of urea derivatives, heterocycles, and carbamoyl fluorides under metal- and additive-free conditions. The reactions are rapid, efficient, selective, and versatile, and can be performed in benign solvents, giving products in excellent yields with minimal efforts for purification. The characteristics of the reactions meet the requirements of a click reaction. The use of trifluoromethyl trifluoromethanesulfonate as a click reagent is advantageous over other “CO” sources (e.g., TsOCF3, PhCO2CF3, CsOCF3, AgOCF3, and triphosgene) because this reagent is readily accessible; easy to scale up; and highly reactive, even under metal- and additive-free conditions. It is anticipated that CF3SO3CF3 will be increasingly as important as SO2F2 as a click agent in future drug design and development.