95759-10-7

Basic information

• Product Name: 4-Chloro-2-(Z)-methoxycarbonylmethoxyimino-3-oxobutyric acid
• Synonyms: 4-chloro-2-(Z)-methoxycarbonyl methoxyimino-3-oxobutyric acid cas:;4-Chioro-2-(Z)-Methoxycarbonyl Methoxyimino-3-Oxobutyric Acid;4-CHIORO-2-(Z)-METHOXYCARBONYL METHOXYIMINO-3-OXOBUTYRIC ACID,=97.5%;4-Chloro-2-(Z)-methoxycarbonylmethoxyimino-3-oxobutyric acid;4-Chloro-2-[(2-methoxy-2-oxoethoxy)imino]-3-oxobutanoic acid;BUTANOICACID,4-CHLORO-2-[(2-METHOXY-2-OXOETHOXY)IMINO]-3-OXO;4-Chioro-2-(Z)-Methoxycarbonyl...;4-Chloro-2-(Z)-methoxycarbonylmethoxyimino-3-oxobutyric acid###4-chloro-2-(Z)-methoxycarbonyl methoxyimino-3-oxobutyric acid cas:95759-10-7
• CAS NO: 95759-10-7
• Molecular Formula: C₇H₈ClNO₆
• Molecular Weight: 237.59
• Mol File: 95759-10-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 364.8 °C at 760 mmHg
• Flash Point: 174.4 °C
• Appearance: /
• Density: 1.47
• PKA: 1.68±0.12(Predicted)
• CAS DataBase Reference: 4-Chloro-2-(Z)-methoxycarbonylmethoxyimino-3-oxobutyric acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-2-(Z)-methoxycarbonylmethoxyimino-3-oxobutyric acid(95759-10-7)
• EPA Substance Registry System: 4-Chloro-2-(Z)-methoxycarbonylmethoxyimino-3-oxobutyric acid(95759-10-7)

Safety Data

• Hazardous Substances Data: 95759-10-7(Hazardous Substances Data)

Usage

General Description

4-Chloro-2-(Z)-methoxycarbonylmethoxyimino-3-oxobutyric acid is a chemical compound with the molecular formula C7H8ClNO7. It is a derivative of the amino acid, glutamine, and is used in the synthesis of pharmaceuticals and organic compounds. 4-Chloro-2-(Z)-methoxycarbonylmethoxyimino-3-oxobutyric acid is a white crystalline solid with a melting point of 160-165 °C and a molecular weight of 235.59 g/mol. It is primarily used as a building block in organic synthesis and in the preparation of various pharmaceutical products. Additionally, it has potential applications in the field of medicinal chemistry and drug discovery due to its unique chemical structure and properties. Overall, 4-Chloro-2-(Z)-methoxycarbonylmethoxyimino-3-oxobutyric acid plays a crucial role in the development of pharmaceuticals and chemical research.

Synthetic route

C11H17NO6 → 4-chloro-2-[(methoxycarbonyl)methoxyimino]-3-oxo-butyric acid (95759-10-7)

Conditions	Yield
With sulfuryl dichloride; acetic acid at 30 - 35℃; Large scale;	110 kg

4-chloro-2-[(methoxycarbonyl)methoxyimino]-3-oxo-butyric acid (95759-10-7) → C7H7Cl2NO5

Conditions	Yield
With trichlorophosphate In tetrahydrofuran; N,N-dimethyl-formamide at -10℃; for 1h;

4-chloro-2-[(methoxycarbonyl)methoxyimino]-3-oxo-butyric acid (95759-10-7) + thiourea (17356-08-0) → 2-(2-aminothiazol-4-yl)-2-methoxycarbonylmethoxyiminoacetic acid

Conditions	Yield
With sodium acetate In water at 20℃; Large scale;	80 kg

Upstream product

• 268544-50-9 C₁₁H₁₇NO₆ 

Relevant articles and documents

A method for producing the active MICA environmental protection (by machine translation)

A active MICA environment-friendly production method, comprises the following steps: oximation, alkylation, chlorinated, ring, process for preparing the intermediate. The invention realizes the recycled, thereby reducing the cost, reduces the amount of waste and waste water; will be S1 in the recrystallization of the sodium acetate as by-product, for S4 in the ring, reducing the waste water and its salt content; in S2 in, now process generally utilizes a potassium carbonate to provide alkaline environment, general in the consumption of 2 more than one equivalent, shortcomings are as follows: a, in the salt in the reaction process too big stirring strenous, b, post-processing needs a large amount of water dissolved inorganic salt, form a large amount of high salt waste water, is changed into the organic base after the solid salt in the reaction process is greatly reduced, post-processing of organic base recycling, reducing the cost and amount of waste water; S3 using batch feeding mode, can be reduced under the same conversion rate, the amount of sulfonyl chloride; S5 recycling reaction generated by-product 2 - mercaptobenzothiazole, recycled in the synthesis of disulphide diphenyl thiazole. (by machine translation)