957761-58-9

Basic information

• Product Name: 4-phenyl-2-(2-(1-(pyridin-3-yl)ethylidene)hydrazinyl)thiazole
• Synonyms: 4-phenyl-2-(2-(1-(pyridin-3-yl)ethylidene)hydrazinyl)thiazole
• CAS NO: 957761-58-9
• Molecular Weight: 294.38
• Mol File: 957761-58-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-phenyl-2-(2-(1-(pyridin-3-yl)ethylidene)hydrazinyl)thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-phenyl-2-(2-(1-(pyridin-3-yl)ethylidene)hydrazinyl)thiazole(957761-58-9)
• EPA Substance Registry System: 4-phenyl-2-(2-(1-(pyridin-3-yl)ethylidene)hydrazinyl)thiazole(957761-58-9)

Safety Data

• Hazardous Substances Data: 957761-58-9(Hazardous Substances Data)

Upstream product

• 1122-54-9 methyl (4-pyridyl) ketone 
• 70-11-1 α-bromoacetophenone 
• 13370-86-0 2-[1-(pyridine-3-yl)ethylidene]hydrazinecarbothioamide 
• 350-03-8 methyl-3-pyridylketone 

Relevant articles and documents

Exploring 4-substituted-2-thiazolylhydrazones from 2-, 3-, and 4-acetylpyridine as selective and reversible hMAO-B inhibitors

A series of 4-substituted-2-thiazolylhydrazone derivatives have been synthesized and tested in vitro for their human monoamine oxidase (hMAO) A and B inhibitory activity. Our findings confirmed that the substitution at C4 of the thiazole ring was important to obtain highly potent and selective hMAO-B inhibitors with IC50 values in the nanomolar range. Moreover, these derivatives were endowed with a reversible mechanism of enzyme inhibition. Molecular modelling studies were performed to rationalize the recognition of all inhibitors with respect to hMAO-A and -B isoforms.