958871-82-4

Basic information

• Product Name: C₃₀H₄₄N₇O₁₈P₃S
• CAS NO: 958871-82-4
• Molecular Weight: 915.703
• Mol File: 958871-82-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₀H₄₄N₇O₁₈P₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₀H₄₄N₇O₁₈P₃S(958871-82-4)
• EPA Substance Registry System: C₃₀H₄₄N₇O₁₈P₃S(958871-82-4)

Safety Data

• Hazardous Substances Data: 958871-82-4(Hazardous Substances Data)

Upstream product

• 1245729-61-6 C₂₉H₄₂N₇O₁₈P₃S 
• 14031-35-7 S-Adenosyl-L-methionine 
• 3921-12-8 3,6-dimethylsalicylic acid 
• 85-61-0 coenzyme A 

Relevant articles and documents

Enediyne antitumor antibiotic maduropeptin biosynthesis featuring a C-methyltransferase that acts on a COA-Tethered aromatic substrate

The enediyne antitumor antibiotic maduropeptin (MDP) is produced by Actinomadura madurae ATCC 39144. The biosynthetic pathway for the 3,6-dimethylsalicylic acid moiety of the MDP chromophore is proposed to be comprised of four enzymes: MdpB, MdpB1, MdpB2, and MdpB3. Based on the previously characterized biosynthesis of the naphthoic acid moiety of neocarzinostatin (NCS), we expected a biosynthetic pathway featuring carboxylic acid activation by the MdpB2 CoA ligase immediately before its coupling to an enediyne core intermediate. Surprisingly, the MDP aromatic acid biosynthetic pathway employs an unusual logic in which MdpB2-catalyzed CoA activation occurs before MdpB1-catalyzed C-methylation, demonstrating that MdpB1 is apparently unique in its ability to C-methylate a CoA-tethered aromatic acid. MdpB2 is a promiscuous CoA ligase capable of activating a variety of salicylic acid analogues, a property that could be potentially exploited to engineer MDP analogues.