959616-36-5

Basic information

• Product Name: 7-BroMo-1,5-naphthyridin-2(1H)-one
• Synonyms: 7-BroMo-1,5-naphthyridin-2(1H)-one;7-Bromo-1,5-naphthyridine-2(1H)-one;7-bromo-1,5-naphthyridin-2-ol
• CAS NO: 959616-36-5
• Molecular Formula: C₈H₅BrN₂O
• Molecular Weight: 225.0421
• Mol File: 959616-36-5.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7-BroMo-1,5-naphthyridin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-BroMo-1,5-naphthyridin-2(1H)-one(959616-36-5)
• EPA Substance Registry System: 7-BroMo-1,5-naphthyridin-2(1H)-one(959616-36-5)

Safety Data

• Hazardous Substances Data: 959616-36-5(Hazardous Substances Data)

Usage

Description

7-Bromo-1,5-naphthyridin-2(1H)-one is a heterocyclic chemical compound with the molecular formula C8H5BrN2O. It features a naphthyridine ring system, which is fused with a bromine atom and a carbonyl group. 7-Bromo-1,5-naphthyridin-2(1H)-one holds promise in medicinal chemistry due to its potential biological activities, such as antimicrobial and antifungal properties.

Uses

Used in Pharmaceutical Development:
7-Bromo-1,5-naphthyridin-2(1H)-one is used as a chemical intermediate for the synthesis of new pharmaceuticals, leveraging its potential antimicrobial and antifungal properties. Its unique structure and properties make it a promising candidate for developing novel drugs to combat resistant infections.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 7-Bromo-1,5-naphthyridin-2(1H)-one serves as a valuable compound for research purposes. Scientists can use it to explore its biological activities and understand its mechanism of action, which can contribute to the advancement of drug discovery and the creation of effective treatments.

Upstream product

• 56247-24-6 3-bromo-1,5-naphthyridine-5-oxide 
• 13535-01-8 3-amino-5-bromopyridine 
• 27305-48-2 1,5-naphthyridine N-⁽¹⁾-oxide 
• 462-08-8 pyridin-3-ylamine 
• 17965-71-8 3-bromo-1,5-naphthyridine 
• 254-79-5 1,5-naphthyridine 

Downstream Products

• 1350925-07-3 1-(4-methoxybenzyl)-7-bromo-1,5-naphthyridin-2(1H)-one 
• 1309774-03-5 7-bromo-2-chloro-1,5-naphthyridine 
• 1350925-08-4 1-(4-methoxybenzyl)-7-(3-hydroxyazetidin-1-yl)-1,5-naphthyridin-2(1H)-one 
• 1350925-09-5 1-(4-methoxybenzyl)-7-(3-oxoazetidin-1-yl)-1,5-naphthyridin-2(1H)-one 
• 1350925-10-8 1-(4-methoxybenzyl)-7-(3-(4-isopropylpiperazin-1-yl)azetidin-1-yl)-1,5-naphthyridin-2(1H)-one 

Relevant articles and documents

SUBSTITUTED 1,5-NAPHTHYRIDINES OR QUINOLINES AS ALK5 INHIBITORS

The present disclosure provides inhibitors of activin receptor-like kinase 5 (ALK5). Also disclosed are methods to modulate the activity of ALK5 and methods of treatment of disorders mediated by ALK5.

ALK5 INHIBITORS

The present disclosure provides inhibitors of activin receptor-like kinase 5 (ALK5). Also disclosed are methods to modulate the activity of ALK5 and methods of treatment of disorders mediated by ALK5.

Design and synthesis of novel substituted naphthyridines as potential c-Met kinase inhibitors based on MK-2461

Abstract Two series of novel 1,5-naphthyridine and 1,6-naphthyridine derivatives were designed and synthesized based on the c-Met kinase inhibitor MK-2461 under the guidance of scaffold hopping strategy. All were tested on c-Met kinase and in vitro anti-tumor activities against Hela and A549 cell lines. The results indicated that 1,6-naphthyridine was a more promising c-Met inhibitory structure core compared with 1,5-naphthyridine. Among them, 26b and 26c showed the best enzymic and cytotoxic activities. The western blot experiments implied that the cytotoxic activity of 26c might be partially through suppressing the phosphorylation of c-Met kinase.