959746-77-1

Basic information

• Product Name: CyclopropanecarboxaMide, N-[3-(2-Methoxyethyl)-4,5-diMethyl-2(3H)-thiazolylidene]-2,2,3,3-tetraMethyl-, [N(Z)]-
• Synonyms: CyclopropanecarboxaMide, N-[3-(2-Methoxyethyl)-4,5-diMethyl-2(3H)-thiazolylidene]-2,2,3,3-tetraMethyl-, [N(Z)]-;1-(tetrahydropyran-4-ylMethyl)-1H-indol-3-yl]-(2,2,3,5-tetraMethylcyclopropyl)Methanone
• CAS NO: 959746-77-1
• Molecular Formula: C16H26N2O2S
• Molecular Weight: 310.45484
• EINECS: -0
• Product Categories: HFC80015
• Mol File: 959746-77-1.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 388.4±44.0 °C(Predicted)
• Appearance: /
• Density: 1.14±0.1 g/cm3(Predicted)
• PKA: -3.95±0.60(Predicted)
• CAS DataBase Reference: CyclopropanecarboxaMide, N-[3-(2-Methoxyethyl)-4,5-diMethyl-2(3H)-thiazolylidene]-2,2,3,3-tetraMethyl-, [N(Z)]-(CAS DataBase Reference)
• NIST Chemistry Reference: CyclopropanecarboxaMide, N-[3-(2-Methoxyethyl)-4,5-diMethyl-2(3H)-thiazolylidene]-2,2,3,3-tetraMethyl-, [N(Z)]-(959746-77-1)
• EPA Substance Registry System: CyclopropanecarboxaMide, N-[3-(2-Methoxyethyl)-4,5-diMethyl-2(3H)-thiazolylidene]-2,2,3,3-tetraMethyl-, [N(Z)]-(959746-77-1)

Safety Data

• Hazardous Substances Data: 959746-77-1(Hazardous Substances Data)

Usage

Description

Cyclopropanecarboxamide, N-[3-(2-methoxyethyl)-4,5-dimethyl-2(3H)-thiazolylidene]-2,2,3,3-tetramethyl-, [N(Z)]-, also known as A-836339, is a synthetic cannabinoid with a higher affinity for the peripheral CB2 receptor (Ki = 0.64 nM) compared to the central CB1 receptor (Ki = 270 nM). It exhibits analgesic, anti-inflammatory, and anti-hyperalgesic effects in mice. At higher doses, A-836339 also reduces spontaneous locomotor activities, which is consistent with CB1 activation. CyclopropanecarboxaMide, N-[3-(2-Methoxyethyl)-4,5-diMethyl-2(3H)-thiazolylidene]-2,2,3,3-tetraMethyl-, [N(Z)]is intended for forensic and research applications.

Uses

Used in Pharmaceutical Research:
Cyclopropanecarboxamide, N-[3-(2-methoxyethyl)-4,5-dimethyl-2(3H)-thiazolylidene]-2,2,3,3-tetramethyl-, [N(Z)]is used as a research compound for studying the effects and mechanisms of action of cannabinoids, particularly in the context of the CB2 receptor. Its higher affinity for CB2 makes it a valuable tool for investigating the therapeutic potential of targeting this receptor in various diseases and conditions.
Used in Forensic Applications:
In forensic science, A-836339 is utilized for the detection and analysis of synthetic cannabinoids in biological samples. Its unique chemical structure and receptor binding profile allow for accurate identification and differentiation from other cannabinoids, aiding in the investigation of drug-related crimes and substance abuse cases.
Used in Drug Development:
Cyclopropanecarboxamide, N-[3-(2-methoxyethyl)-4,5-dimethyl-2(3H)-thiazolylidene]-2,2,3,3-tetramethyl-, [N(Z)]is employed in the development of novel therapeutic agents targeting the CB2 receptor. Its analgesic, anti-inflammatory, and anti-hyperalgesic properties make it a promising candidate for the treatment of pain and inflammation-related disorders. Additionally, its effects on spontaneous locomotor activities at higher doses provide insights into the potential side effects and optimal dosing strategies for cannabinoid-based medications.