960388-60-7

Basic information

• Product Name: (3-bromophenyl)(4-methoxyphenyl)methylamine
• Synonyms: (3-bromophenyl)(4-methoxyphenyl)methylamine
• CAS NO: 960388-60-7
• Molecular Weight: 292.175
• Mol File: 960388-60-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 399.9±37.0 °C(Predicted)
• Density: 1.368±0.06 g/cm3(Predicted)
• CAS DataBase Reference: (3-bromophenyl)(4-methoxyphenyl)methylamine(CAS DataBase Reference)
• NIST Chemistry Reference: (3-bromophenyl)(4-methoxyphenyl)methylamine(960388-60-7)
• EPA Substance Registry System: (3-bromophenyl)(4-methoxyphenyl)methylamine(960388-60-7)

Safety Data

• Hazardous Substances Data: 960388-60-7(Hazardous Substances Data)

Upstream product

• 623-00-7 4-bromobenzenecarbonitrile 
• 54118-76-2 (3-bromophenyl)(4-methoxyphenyl)methanone 
• 1711-09-7 3-bromobenzoyl chloride 
• 1428526-48-0 C₁₅H₁₄BrNO₂ 
• 100-66-3 methoxybenzene 
• 6952-59-6 3-cyanobromobenzene 

Downstream Products

• 960388-64-1 1-bromo-3-[isothiocyanato(4-methoxyphenyl)methyl]benzene 
• 1428526-50-4 C₁₉H₂₂BrNO₃ 
• 1428526-51-5 C₂₃H₃₂NO₆P 
• 1428526-52-6 diethyl 3-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenylphosphonate 
• 1428526-53-7 3-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenylphosphonic acid 
• 960389-27-9 8-(3-bromophenyl)-3-hydroxy-8-(4-methoxyphenyl)-3,4,7,8-tetrahydroimidazo[1,5-a]pyrimidine-6(2H)-thione 
• 960389-31-5 8-(3-bromophenyl)-8-(4-methoxyphenyl)-6-thioxo-2,3,4,6,7,8-hexahydroimidazo[1,5-a]pyrimidine-3-carbonitrile 
• 960389-41-7 8-(3-bromophenyl)-3,3-difluoro-8-(4-methoxyphenyl)-3,4,7,8-tetrahydroimidazo[1,5-a]pyrimidine-6(2H)-thione 
• 960389-33-7 methyl 8-(3-bromophenyl)-8-(4-methoxyphenyl)-6-thioxo-2,3,4,6,7,8-hexahydroimidazo[1,5-a]pyrimidine-3-carboxylate 
• 960389-25-7 8-(3-bromophenyl)-8-(4-methoxyphenyl)-3-(methylsulfonyl)-3,4,7,8-tetrahydroimidazo[1,5-a]pyrimidine-6(2H)-thione 
• 960389-37-1 N-[8-(3-bromophenyl)-8-(4-methoxyphenyl)-6-thioxo-2,3,4,6,7,8-hexahydroimidazo[1,5-a]pyrimidine-3-yl]methanesulfonamide 
• 960389-39-3 (4S)-8-(3-bromophenyl)-8-(4-methoxyphenyl)-6-thioxo-2,3,4,6,7,8-hexahydroimidazo[1,5-a]pyrimidine-4-carboxylic acid 
• 960389-29-1 8-(3-bromophenyl)-3-methoxy-8-(4-methoxyphenyl)-3,4,7,8-tetrahydroimidazo[1,5-a]pyrimidine-6(2H)-thione 
• 960389-45-1 8-(3-bromophenyl)-8-(4-methoxyphenyl)-3-(methylsulfonyl)-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidine-6-amine 

Relevant articles and documents

SUBSTITUTED PYRIMIDINES

The present invention relates to substituted pyrimidines useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.

Aminoimidazoles as potent and selective human β-secretase (BACE1) inhibitors

The identification of small molecule aminoimidazoles as potent and selective human β-secretase inhibitors is reported. These analogues demonstrate low nannomolar potency for BACE1 in a FRET assay, exhibit comparable activity in a cell-based (ELISA) assay, and show>100x selectivity for the other structurally related aspartyl proteases BACE2, cathepsin D, renin, and pepsin. Our design strategy was supported by molecular modeling studies based on the cocrystal structure of the HTS-hit 3 in the BACE1 active site. These strategies enabled us to integrate pyridine and pyrimidine groups on 3 extending deep into the S3 region of the BACE1 binding pocket and enhancing the ligand's potency. Compound (R)-37 displayed an IC50 value for BACE1 of 20 nM, cellular activity of 90 nM, and > 100-fold selectivity over related aspartyl proteases. Acute oral administration of (R)-37 at 30 mg/kg resulted in a significant 71% reduction of plasma Aβ40 measured at the 6 h time point in a Tg2576 mouse model (p 0.001). 2009 American Chemical Society.

AMINO-IMIDAZOLONES AND THEIR USE AS A MEDICAMENT FOR TREATING COGNITIVE IMPAIRMENT, ALZHEIMER DISEASE, NEURODEGENERATION AND DEMENTIA

This invention relates to novel compounds having the structural formula I below: and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Di