96479-87-7

Basic information

• Product Name: falintolol
• Synonyms: (2R)-1-(tert-butylamino)-3-[(Z)-1-cyclopropylethylideneamino]oxypropan-2-ol;Ethanone, 1-cyclopropyl-, O-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl]oxime, [R-(E)]- (9CI)
• CAS NO: 96479-87-7
• Molecular Formula: C12H24N2O2
• Molecular Weight: 228.33116
• Mol File: 96479-87-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 343.6°Cat760mmHg
• Flash Point: 161.6°C
• Appearance: /
• Density: 1.07g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.509
• PKA: 14.32±0.20(Predicted)
• CAS DataBase Reference: falintolol(CAS DataBase Reference)
• NIST Chemistry Reference: falintolol(96479-87-7)
• EPA Substance Registry System: falintolol(96479-87-7)

Safety Data

• Hazardous Substances Data: 96479-87-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H24N2O2/c1-9(10-5-6-10)14-16-8-11(15)7-13-12(2,3)4/h10-11,13,15H,5-8H2,1-4H3/b14-9+/t11-/m1/s1

Upstream product

• 96428-14-7 (anti)-cyclopropyl methyl ketone oxime sodium salt 
• 75-64-9 tert-butylamine 
• 96479-95-7 1-Cyclopropyl-ethanone O-oxiranylmethyl-oxime 
• 88135-05-1 (2R)-O-(1,2-epoxypropyl)cyclopropyl methyl ketone oxime 
• 88135-05-1 (2S)-O-(1,2-epoxypropyl)cyclopropyl methyl ketone oxime 
• 88135-05-1 1-Cyclopropyl-ethanone O-oxiranylmethyl-oxime 
• 765-43-5 Cyclopropyl methyl ketone 
• 67435-25-0 1-aminooxy-3-[(1,1-dimethyl-ethyl)-amino]-2-hydroxy-propane 
• 51761-72-9 cyclopropyl methyl ketone oxime 

Relevant articles and documents

New chiral and isomeric cyclopropyl ketoxime propanolamine derivatives with potent β-adrenergic blocking properties

The synthesis of R-(+) and s-(-)isomers of O-[3-(tert-butylamino)-2-hydroxypropyl] cyclopropyl methyl ketone oxime (falintolol) is described. The syn and anti isomers of falintolol were obtained in two different ways from cyclopropyl methyl ketoxime or from falintolol. For comparison purposes, the enantiomers of the dicyclopropyl ketone oxime derivatives were also prepared. Structure-activity relationships are described.