96600-76-9Relevant articles and documents
Nucleophilic Chlorination of 3-Formyl-4-hydroxy-quinolin-2(1H)-ones
Fiala, Werner,Stadlbauer, Wolfgang
, p. 128 - 134 (2007/10/02)
Chlorination of 1-substituted 3-formyl-4-hydroxy-2-quinolones (1a, b) with phosphorylchloride leads to 4-chloro-3-dichloromethylquinolones (2), which can be hydrolyzed to 4-chloro-3-formylquinolones (4).From the anilinomethylene quinolinediones (3), at lo
Chemistry of Carbostyril: Part I - Oxidation Reactions of 4-Hydroxy- and 4-Hydroxy-1-methyl-2(1H)-quinolinones
Khan, Khalid A.,Shoeb, Aboo
, p. 62 - 66 (2007/10/02)
4-Hydroxy-2(1H)-quinolinone (1) reacts with acetic anhydride in dimethylsulphoxide at 100 deg to afford 3-dimethylsulfonioquinoline-2,4-dionate (3) whereas 3,3'-methylenebis (4) and 2,3,4,5,1',2',3',4'-octahydro-4,2',4'-trioxospioroquinoline-2,3'-quinoline> (5) are formed when the reaction is carried out at 165-70 deg.The involvement of 4 as a precursor of 5 has been demonstrated.Probable mechanisms of their formation have been proposed.The behaviour of 4-hydroxy-1-methyl-2(1H)-quinolinone (2) towards other oxidising agents, such as HNO3, CrO3, SOCl2-DMF and p-benzoquinone has also been studied.