96687-22-8 Usage
Type of lipid
DOPE-DM is a type of lipid commonly used in the formulation of liposomes and lipid nanoparticles.
Composition
It is composed of two oleic acid chains attached to a glycerol backbone, with a phosphoethanolamine headgroup and a dimethylamine group attached to the phosphoethanolamine.
Application
DOPE-DM is widely used in the field of drug delivery.
Stability and biocompatibility
It has the ability to form stable and biocompatible lipid bilayers, making it an ideal component for encapsulating and delivering therapeutic agents to specific targets within the body.
Encapsulation and release of nucleic acids
The presence of the dimethylamine group facilitates the efficient encapsulation and release of nucleic acids.
Gene delivery
DOPE-DM is a valuable tool for gene delivery in biomedical research and clinical applications.
Structure
The structure of DOPE-DM consists of a glycerol backbone with two oleic acid chains, a phosphoethanolamine headgroup, and a dimethylamine group attached to the phosphoethanolamine.
Role in drug delivery
DOPE-DM plays a crucial role in the encapsulation and delivery of therapeutic agents, including nucleic acids, to specific targets within the body.
Advantages
The advantages of using DOPE-DM in drug delivery include its ability to form stable and biocompatible lipid bilayers, efficient encapsulation and release of nucleic acids, and its wide applicability in biomedical research and clinical applications.
Check Digit Verification of cas no
The CAS Registry Mumber 96687-22-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,6,6,8 and 7 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 96687-22:
(7*9)+(6*6)+(5*6)+(4*8)+(3*7)+(2*2)+(1*2)=188
188 % 10 = 8
So 96687-22-8 is a valid CAS Registry Number.
96687-22-8Relevant articles and documents
Surface-differentiated model phospholipid bilayers
Moss, Robert A.,Okumura, Yukihisa
, p. 1750 - 1756 (2007/10/02)
Dipalmitoylphosphatidylcholine (DPPC) and dioleoylphosphatidylcholine (DOPC) were synthesized in which the head groups were covalently functionalized with p-nitrophenyl benzoate (PNPB) moieties. Liposomes composed of 1 part functional lipid and 7 parts nonfunctional DPPC or DOPC were created at pH 6 and subjected to an exovesicular/endovesicular 12/6 pH gradient. Under these conditions, the exovesicular PNPB groups saponified more rapidly (k ～ 4.5 × 10-2 s-1) than the endovesicular PNPB groups [k ～ 7 × 10-6 s-1 (DPPC) or 7 × 10-5 s-1 (DOPC)], leading to surface-differentiated liposomes with exovesicular p-nitrophenylate labels and intact, endovesicular PNPB groups. The half-times for flip-flop reequilibration of the intact PNPB lipids between the endovesicular and exovesicular leaflets of the liposomal bilayers were (DPPC) ～ 6 min at 65 °C and (DOPC) ～ 20 min at 65 °C. The permeabilities of these liposomes to H+/OH- were also studied. Comparisons of the DPPC and DOPC flip-flop dynamics to those of analogous, cationic, ammonium ion lipids highlight the relative dynamic stability of the zwitterionic phospholipids in liposomal bilayers.
