96783-68-5

Basic information

• Product Name: N-(3-AMINOMETHYL-PHENYL)-ACETAMIDE
• Synonyms: N-(3-AMINOMETHYL-PHENYL)-ACETAMIDE;3-AcetaMidobenzylaMine
• CAS NO: 96783-68-5
• Molecular Formula: C₉H₁₂N₂O
• Molecular Weight: 164.2
• Mol File: 96783-68-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 372.2±25.0 °C(Predicted)
• Appearance: /
• Density: 1.152±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 14.98±0.70(Predicted)
• CAS DataBase Reference: N-(3-AMINOMETHYL-PHENYL)-ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-AMINOMETHYL-PHENYL)-ACETAMIDE(96783-68-5)
• EPA Substance Registry System: N-(3-AMINOMETHYL-PHENYL)-ACETAMIDE(96783-68-5)

Safety Data

• Hazardous Substances Data: 96783-68-5(Hazardous Substances Data)

Usage

General Description

N-(3-Aminomethyl-phenyl)-acetamide is a chemical compound with the molecular formula C9H12N2O. It is also known by the name "Parachlorometacetamide" and is used as an intermediate in the pharmaceutical industry for the synthesis of various medications. This chemical is a white solid that is soluble in organic solvents and has a melting point of about 168-172°C. N-(3-Aminomethyl-phenyl)-acetamide has potential applications in drug development and research due to its pharmacological properties and ability to interact with biological systems. Additionally, it is important to handle and use this compound with caution as it may have harmful effects if not handled properly.

Upstream product

• 58202-84-9 N-(3-cyanophenyl)acetamide 
• 903556-11-6 tert-butyl 3-acetamidobenzylcarbamate 

Downstream Products

• 1114978-92-5 (E)-N-(3-acetamidobenzyl)-5-(2-(4-methoxybenzylidene)hydrazinyl)-3-methyl-1H-pyrazole-4-carboxamide 
• 1600521-00-3 C₁₇H₂₁N₃O₃ 
• 1355772-06-3 C₁₈H₂₂N₄O₂ 
• 1333728-05-4 C₁₉H₂₅N₃O₃ 
• 1581755-39-6 (R)-N-(3-acetamidobenzyl)-1-(1-(naphthalen-1-yl)ethyl)-piperidine-4-carboxamide 
• 918811-11-7 Ethyl 2-(3-acetamidobenzylamino)acetate 
• 59755-25-8 3-acetylaminobenzaldehyde 

Relevant articles and documents

Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2

The COVID-19 pandemic has been disastrous to society and effective drugs are urgently needed. The papain-like protease domain (PLpro) of SARS-CoV-2 (SCoV2) is indispensable for viral replication and represents a putative target for pharmacological intervention. In this work, we describe the development of a potent and selective SCoV2 PLpro inhibitor, 19. The inhibitor not only effectively blocks substrate cleavage and immunosuppressive function imparted by PLpro, but also markedly mitigates SCoV2 replication in human cells, with a submicromolar IC50. We further present a convenient and sensitive activity probe, 7, and complementary assays to readily evaluate SCoV2 PLpro inhibitors in vitro or in cells. In addition, we disclose the co-crystal structure of SCoV2 PLpro in complex with a prototype inhibitor, which illuminates their detailed binding mode. Overall, these findings provide promising leads and important tools for drug discovery aiming to target SCoV2 PLpro.