96790-73-7Relevant articles and documents
Production of hydroxlated flavonoids with cytochrome P450 BM3 variant F87V and their antioxidative activities
Kitamura, Emi,Otomatsu, Toshihiko,Maeda, Chiemi,Aoki, Yoko,Ota, Chihiro,Misawa, Norihiko,Shindo, Kazutoshi
, p. 1340 - 1343 (2013/07/26)
A variant of P450 BM3 with an F87V substitution [P450 BM3 (F87V)] is a substrate-promiscuous cytochrome P450 monooxygenase. We investigated the bioconversion of various flavonoids (favanones, chalcone, and isoflavone) by using recombinant Escherichia coli cells, which expressed the gene coding for P450 BM3 (F87V), to give their corresponding hydroxylated products. Potent antioxidative activities were observed in some of the products.
Facile epoxidation of α,β-unsaturated ketones with cyclohexylidenebishydroperoxide
Jakka, Kavitha,Liu, Jinyun,Zhao, Cong-Gui
, p. 1395 - 1398 (2007/10/03)
Cyclohexylidenebishydroperoxide was successfully used as the oxygen source for the oxidation of α,β-unsaturated ketones for the first time. The corresponding epoxides were obtained in excellent yields under the Weitz-Scheffer reaction conditions.
Synthetic studies towards the preparation of 2-benzyl-2-hydroxybenzofuran- 3(2H)-one, the prototype of naturally occurring hydrated auronols
Loeser, Reik,Chlupacova, Marta,Marecek, Ales,Opletalova, Veronika,Guetschow, Michael
, p. 2597 - 2601 (2007/10/03)
Various synthetic approaches were employed to prepare 2-benzyl-2- hydroxybenzofuran-3(2H)-one (8), the prototype of naturally occurring auronols. While the base-induced ring transformation of 3-hydroxyflavanone (2) as well as the hydration of 2-benzylidenebenzofuran-3(2H)-one (=aurone; 6) proved to be inappropriate, the hydrogenolytic epoxide-ring opening of 2′- phenylspiro[benzofuran-2(3H),2′-oxiran]-3-one (7), obtained from 6, represents an efficient method to afford the auronol 8.