96853-42-8

Basic information

• Product Name: 4-(2-Nitroethyl)benzene-1,3-diol
• Synonyms: 4-(2-Nitroethyl)benzene-1,3-diol
• CAS NO: 96853-42-8
• Molecular Weight: 183.164
• Mol File: 96853-42-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-(2-Nitroethyl)benzene-1,3-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-Nitroethyl)benzene-1,3-diol(96853-42-8)
• EPA Substance Registry System: 4-(2-Nitroethyl)benzene-1,3-diol(96853-42-8)

Safety Data

• Hazardous Substances Data: 96853-42-8(Hazardous Substances Data)

Upstream product

• 96853-35-9 5-hydroxy-2-(2-nitroethenyl) phenol 
• 95-01-2 2,4-Dihydroxybenzaldehyde 
• 96853-35-9 5-Hydroxy-2-(2-nitroethenyl)-phenol 

Downstream Products

• 13196-11-7 6-hydroxybenzofuran 
• 66486-61-1 4-phenyl-psoralen 
• 14159-13-8 5-methyl-7H-furan[3,2-g]benzopyran-7-one 
• 66-97-7 psoralen 

Relevant articles and documents

Structural modification of a specific antimicrobial lead against Helicobacter pylori discovered from traditional Chinese medicine and a structure-activity relationship study

Psoralen (1a) was found to be a specific and potent antimicrobial lead against Helicobacter pylori (H. pylori) from a traditional Chinese medicine (TCM) in the bioassay directed isolation. A series of structurally diverse analogues of 1a were thus designed and synthesized to improve the antimicrobial potency, some of which showed more potent activities than the lead compound (1a) against H. pylori. Among them, compound 25a is 16-fold stronger (MIC = 0.39 μg/mL) than 1a (MIC = 6.25 μg/mL), and is even potent than the positive control metronidazole (MIC = 0.50 μg/mL). The in vitro antimicrobial activities against H. pylori of these structurally diverse analogues based on the scaffold of 1a have also led to an outline of structure-activity relationship.

A Convenient Synthesis of 2-(2-Nitroethyl)-Phenols

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