97-97-2

Basic information

• Product Name: Chloroacetaldehyde dimethyl acetal
• Synonyms: 2-Chlor-1,1-dimethoxyethan;CHLORACETALDEHYDDIMETHYLACETAL;2-Chloro-1,1-dimethoxyethane, Dimethyl chloroacetal;2-Chloro-1,1-dimethoxyethane, CADMA, Dimethyl chloroacetal;2,2-Dimethoxyethyl chloride;Chloroacetaldehyde dimethyl acetal,97%;Chloroacetaldehyde d;Chloroacetaldehyde diMethyl acetal, 97% 250ML
• CAS NO: 97-97-2
• Molecular Formula: C₄H₉ClO₂
• Molecular Weight: 124.57
• EINECS: 202-624-0
• Product Categories: Pyridines ,Halogenated Heterocycles;Pharmaceutical Intermediates
• Mol File: 97-97-2.mol
• Article Data: 10

Chemical Properties

• Melting Point: -73 °C
• Boiling Point: 128-130 °C(lit.)
• Flash Point: 84 °F
• Appearance: Clear colorless to yellow/Liquid
• Density: 1.094 g/mL at 25 °C(lit.)
• Vapor Pressure: 13.494mmHg at 25°C
• Refractive Index: n20/D 1.415(lit.)
• Storage Temp.: Flammables area
• Solubility: 52g/l
• Explosive Limit: 2.3%(V)
• Water Solubility: 52 g/L (20 ºC)
• Sensitive: Moisture Sensitive
• BRN: 1733700
• CAS DataBase Reference: Chloroacetaldehyde dimethyl acetal(CAS DataBase Reference)
• NIST Chemistry Reference: Chloroacetaldehyde dimethyl acetal(97-97-2)
• EPA Substance Registry System: Chloroacetaldehyde dimethyl acetal(97-97-2)

Safety Data

• Hazard Codes: Xn,F
• Statements: 10-22-52/53-20/21/22-40-36/37/38
• Safety Statements: 28A-26-16-36-23
• RIDADR: UN 1989 3/PG 3
• WGK Germany: 2
• F: 1
• TSCA: Yes
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 97-97-2(Hazardous Substances Data)

Usage

Uses

Chloroacetaldehyde dimethyl acetal can be used as a reactant to synthesize:2-(chloromethyl)-4,7-dethyl-1,3-dioxepane2-(chloromethyl)-5,6-benzo-1,3-dioxepane ketene dimethyl acetal

General Description

Chloroacetaldehyde dimethyl acetal is a clear, colorless liquid. It reacts with hydroxythiol to form hydroxy acetal.

Purification Methods

Purify the acetal by fractional distillation. [Melhotra J Indian Chem Soc 36 4405 1959, Beilstein 1 IV 3134.]

InChI:InChI=1/C4H9ClO2/c1-6-4(3-5)7-2/h4H,3H2,1-2H3

Upstream product

• 67-56-1 methanol 
• 108-05-4 vinyl acetate 
• 75-07-0 acetaldehyde 
• 75-01-4 chloroethylene 
• 107-20-0 2-chloroethanal 
• 95684-29-0 2-chloro-1-hydroxyethyl 2-chloro-1-methoxyethyl peroxide 
• 10257-28-0 D-Galactose 
• 2280-44-6 D-Glucose 
• 123-63-7 paracetaldehyde 
• 107-25-5 methoxyethene 
• 124-41-4 sodium methylate 
• 41683-62-9 1,2-dichloro-1-methoxy-ethane 

Downstream Products

• 2568-30-1 2-chloromethyl-1,3-dioxolane 
• 38711-20-5 1,1-dimethoxymethyl-N,N-dimethylmethanamine 
• 41593-98-0 N-benzylthiazol-2-amine 
• 3461-34-5 methyl 3,3-diphenylacrylate 
• 69814-57-9 2-methylene-[1,3]dioxocane 
• 106052-96-4 2-Methylene-4-phenoxymethyl-[1,3]dioxolane 
• 120368-13-0 o-(hydroxymethyl)phenoxyacetaldehyde dimethyl acetal 
• 137488-39-2 1-(3'-trifluoromethyl-phenyl)-2-chloromethyl-1,2-dihydro-3,1-benzoxazin-4-one 
• 137488-43-8 1-(1',2'-dimethyl-phenyl)-2-chloromethyl-1,2-dihydro-3,1-benzoxazin-4-one 
• 70280-48-7 3-benzyl-5-chloro-4-methoxy-2-pentanone 
• 101945-55-5 2-chloromethyl-4-o-chlorophenyl-1,2-dihydro-6-nitro-quinazoline 3-oxide 
• 69567-06-2 (N-methylanilino)prop-2-enenitrile 
• 109153-82-4 (1')-2-chloro-1-methoxyethyl 2,3,4,6-tetra-O-benzyl-β-D-glucoyranoside 
• 109153-83-5 (1'S)-2-chloro-1-methoxyethyl 2,3,4,6-tetra-O-benzyl-β-D-glucopyranoside 

Relevant articles and documents

-

-

Green method for preparing chloroacetaldehyde dialkyl alcohol from vinyl ether

The invention discloses a green method for preparing chloroacetaldehyde dialkyl alcohol from vinyl ether. The method takes alkyl vinyl ether, chlorine and alcohol as raw materials and takes corresponding sodium alcoholate as a nucleophilic reagent and comprises the steps: carrying out electrophilic addition on alkyl ether and chlorine in low-boiling-point solvents such as ethers, hydrocarbons, halogenated hydrocarbons and the like; and after chlorination is finished, adding into an alcoholic solution of sodium alcoholate for nucleophilic substitution to obtain high-yield chloroacetaldehyde dialkyl alcohol, such as chloroacetaldehyde dimethyl acetal, chloroacetaldehyde diethyl acetal and chloroacetaldehyde methylisobutyl alcohol. The method is easy to operate, single in reaction, high in yield, less in side reaction, green and pollution-free; the recovered solvent and alcohol can be repeatedly used; no waste acid or waste water is generated in the whole process, the only byproduct sodium chloride can be used for other industrial purposes, and environment-friendly circulation and zero emission are achieved.

Method for preparing aminoacetaldehyde dimethyl acetal

The invention discloses a method for preparing aminoacetaldehyde dimethyl acetal, which comprises the following steps: S1, adding a phase transfer catalyst A and vinyl acetate into a reaction flask, introducing a certain amount of chlorine while stirring, and performing heat-insulation stirring until the color of the reaction solution becomes colorless to obtain a chlorination solution; S2, dropwise adding the chlorination liquid prepared in the step S1 into methanol for reaction to prepare a chloroacetaldehyde dimethyl acetal crude product; S3, transferring the chloroacetaldehyde dimethyl acetal crude product prepared in the step S2 to an autoclave, introducing liquid ammonia, carrying out heating and pressurizing reaction, and after the reaction is finished, adding alkali to adjust the pH value; and S4, decompressing and rectifying the reaction product to obtain the target product, aminoacetaldehyde dimethyl acetal. By adopting the method, high-purity aminoacetaldehyde dimethyl acetal can be prepared, and the industrial production requirement of aminoacetaldehyde dimethyl acetal can be met.