97363-76-3

Basic information

• Product Name: 1-((1R,4aS,10aR)-7-Isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthren-1-yl)-3-phenyl-urea
• CAS NO: 97363-76-3
• Molecular Weight: 390.569
• Mol File: 97363-76-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-((1R,4aS,10aR)-7-Isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthren-1-yl)-3-phenyl-urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-((1R,4aS,10aR)-7-Isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthren-1-yl)-3-phenyl-urea(97363-76-3)
• EPA Substance Registry System: 1-((1R,4aS,10aR)-7-Isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthren-1-yl)-3-phenyl-urea(97363-76-3)

Safety Data

• Hazardous Substances Data: 97363-76-3(Hazardous Substances Data)

Upstream product

• 97363-89-8 18-nordehydroabietyl isocyanate 
• 62-53-3 aniline 
• 1740-19-8 dehydroabietic acid 

Relevant articles and documents

Synthesis, structure analysis and cytotoxicity studies of novel unsymmetrically N,N′-substituted ureas from dehydroabietic acid

A series of novel unsymmetrically N,N′-substituted ureas were synthesized from dehydroabietic acid and their structures were characterized by IR, 1H-NMR, 13C-NMR spectroscopy and single crystal X-ray diffraction. Three six-membered rings of urea 4c exhibited plane, half-chair and chair configurations, respectively. Their cytotoxicity activities against SMMC7721 liver cancer cells were evaluated by MTT (3-(4,5-dimethylthiazol-2-yl)- 2,5-diphenyltetrazolium bromide) method. The results showed that the title compounds exhibited highly effective cytotoxicity activities against SMMC7721 cells. Their IC50 values are between 8.8 and 14.2 μmol/l. The change of N′ substituted groups resulted little difference to the cytotoxicity activities of ureas, which indicated that the cytotoxicity of this kind of ureas depend strongly on the tricyclic hydrophenanthrene structure.