98027-36-2

Basic information

• Product Name: 2-HYDROXY-3-AMINO-5-CHLOROPYRIDINE
• Synonyms: 2-HYDROXY-3-AMINO-5-CHLOROPYRIDINE;3-AMINO-5-CHLORO-2-HYDROXYPYRIDINE;2-Hydroxy-3-amnio-5-chloropyridine;3-Amnio-5-chloro-2-hydroxypyridine;2-Pyridinol,3-amino-5-chloro- (6CI);3-Amino-5-chloro-2(1H)-pyridinone;3-AMino-5-chloropyridin-2(1H)-one;3-Amino-5-chloro-1H-pyridin-2-one
• CAS NO: 98027-36-2
• Molecular Formula: C₅H₅ClN₂O
• Molecular Weight: 144.559
• Product Categories: Pyridine;API intermediates;Heterocycle-Pyridine series
• Mol File: 98027-36-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 423.989oC at 760 mmHg
• Flash Point: 210.221oC
• Appearance: /
• Density: 1.517g/cm3
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.664
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 11.81±0.10(Predicted)
• CAS DataBase Reference: 2-HYDROXY-3-AMINO-5-CHLOROPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-3-AMINO-5-CHLOROPYRIDINE(98027-36-2)
• EPA Substance Registry System: 2-HYDROXY-3-AMINO-5-CHLOROPYRIDINE(98027-36-2)

Safety Data

• Hazardous Substances Data: 98027-36-2(Hazardous Substances Data)

Usage

General Description

2-HYDROXY-3-AMINO-5-CHLOROPYRIDINE is a chemical compound with the molecular formula C5H5ClN2O. It is a derivative of pyridine, containing a chlorine atom and an amino group on the 3rd and 5th carbon atoms, respectively. The hydroxyl group is attached to the 2nd carbon atom. 2-HYDROXY-3-AMINO-5-CHLOROPYRIDINE is commonly used in the synthesis of pharmaceuticals and agrochemicals, as well as in the development of dyes and pigments. It has also been studied for its potential biological activities, including its antifungal and antimicrobial properties, making it a subject of interest for further research in pharmaceutical and agricultural applications.

InChI:InChI=1/C5H5ClN2O/c6-3-1-4(7)5(9)8-2-3/h1-2H,7H2,(H,8,9)

Upstream product

• 21427-61-2 5-chloro-3-nitropyridin-2-ol 

Relevant articles and documents

HETEROCYCLIC COMPOUND

Provided is a heterocyclic compound that may have a GCN2 inhibitory action, and is expected to be useful for the prophylaxis or treatment of GCN2 associated diseases including cancer and the like. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.

Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2] nonane (CP-810,123), a novel α7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: Synthesis, SAR development, and in vivo efficacy in cognition models

A novel α7 nAChR agonist, 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4- diazabicyclo[3.2.2]nonane (24, CP-810,123), has been identified as a potential treatment for cognitive deficits associated with psychiatric or neurological conditions including schizophrenia and Alzheimer's disease. Compound 24 is a potent and selective compound with excellent pharmaceutical properties. In rodent, the compound displays high oral bioavailability and excellent brain penetration affording high levels of receptor occupancy and in vivo efficacy in auditory sensory gating and novel object recognition. The structural diversity of this compound and its preclinical in vitro and in vivo package support the hypothesis that α7 nAChR agonists may have potential as a pharmacotherapy for the treatment of cognitive deficits in schizophrenia. 2009 American Chemical Society.