98049-69-5 Usage
Description
LIPOXIN B4, also known as 5(S),14(R)-Lipoxin B4, is a positional isomer of Lipoxin A4 (LXA4) and belongs to the family of anti-inflammatory lipid mediators. It plays a crucial role in signaling the resolution of inflammation and possesses potent inhibitory effects on leukotriene-triggered polymorphonuclear neutrophil (PMN)-endothelial cell interactions and PMN migration.
Used in Pharmaceutical Industry:
LIPOXIN B4 is used as an anti-inflammatory agent for its ability to inhibit leukotriene-induced PMN migration and adhesion, contributing to the resolution of inflammation. Its concentration of 10^-7 M effectively suppresses PMN migration stimulated by leukotriene B4 (LTB4), with an IC50 value of approximately 3 x 10^-10 M.
Check Digit Verification of cas no
The CAS Registry Mumber 98049-69-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,0,4 and 9 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 98049-69:
(7*9)+(6*8)+(5*0)+(4*4)+(3*9)+(2*6)+(1*9)=175
175 % 10 = 5
So 98049-69-5 is a valid CAS Registry Number.
InChI:InChI=1/C20H32O5/c1-2-3-8-14-18(22)19(23)15-10-7-5-4-6-9-12-17(21)13-11-16-20(24)25/h4-7,9-10,12,15,17-19,21-23H,2-3,8,11,13-14,16H2,1H3,(H,24,25)/b6-4-,7-5+,12-9+,15-10+/t17-,18+,19-/m1/s1
98049-69-5Relevant articles and documents
SYNTHESIS OF 5S-HYDROXY-14,15 LTA4 A BIOGENIC PRECURSOR TO THE LIPOXINS
Leblanc, Yves,Fitzsimmons, Brian J.,Rokach, Joshua
, p. 3449 - 3452 (2007/10/02)
A synthesis of 5S-hydroxy-14,15-LTA4 10 an intermediate in the biosynthesis of the lipoxins is described.
On the biosynthesis and the structure of lipoxin B
Fitzsimmons,Rokach
, p. 3939 - 3942 (2007/10/02)
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