98260-05-0

Basic information

• Product Name: Benzoic acid, 4-(2-propynyloxy)-, methyl ester
• CAS NO: 98260-05-0
• Molecular Formula: C11H10O3
• Molecular Weight: 190.199
• Mol File: 98260-05-0.mol
• Article Data: 25

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-(2-propynyloxy)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-(2-propynyloxy)-, methyl ester(98260-05-0)
• EPA Substance Registry System: Benzoic acid, 4-(2-propynyloxy)-, methyl ester(98260-05-0)

Safety Data

• Hazardous Substances Data: 98260-05-0(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 5651-86-5 4-(prop-2-ynyloxy)benzaldehyde 
• 99-96-7 4-hydroxy-benzoic acid 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 106-96-7 propargyl bromide 

Downstream Products

• 117379-97-2 5-methoxycarbonyl-2-methylbenzofuran 
• 34905-02-7 [4-(prop-2-yn-1-yloxy)phenyl]methanol 
• 1219366-84-3 C₁₂H₉⁽²⁾H₃O₃ 
• 1219366-77-4 C₁₆H₁₆O₃ 
• 1219366-80-9 C₁₆H₁₈O₅ 
• 1219366-68-3 C₁₄H₁₆O₄ 
• 1428739-55-2 4-((1-benzyl-1,2,3-triazol-4-yl)methoxy)benzoic acid methyl ester 
• 1428739-66-5 4-((1-(5-chloro-2-(2,4-dichlorophenoxy)phenyl)-1,2,3-triazol-4-yl)methoxy)benzoic acid methyl ester 
• 21926-55-6 4-(prop-2-ynyloxy)benzoic acid 

Relevant articles and documents

Enantio- and Diastereoselective, Complete Hydrogenation of Benzofurans by Cascade Catalysis

We report an enantio- and diastereoselective, complete hydrogenation of multiply substituted benzofurans in a one-pot cascade catalysis. The developed protocol facilitates the controlled installation of up to six new defined stereocenters and produces architecturally complex octahydrobenzofurans, prevalent in many bioactive molecules. A unique match of a chiral homogeneous ruthenium-N-heterocyclic carbene complex and an in situ activated rhodium catalyst from a complex precursor act in sequence to enable the presented process.

Electro-Oxidative Selective Esterification of Methylarenes and Benzaldehydes

A mild and green electro-oxidative protocol to construct aromatic esters from methylarenes and alcohols is herein reported. Importantly, the reaction is free of metals, chemical oxidants, bases, acids, and operates at room temperature. Moreover, the design of the electrolyte was found critical for the oxidation state and structure of the coupling products, a rarely documented effect. This electro-oxidative coupling process also displays exceptional tolerance of many fragile easily oxidized functional groups such as hydroxy, aldehyde, olefin, alkyne, as well as neighboring benzylic positions. The enantiomeric enrichment of some chiral alcohols is moreover preserved during this electro-oxidative coupling reaction, making it overall a promising synthetic tool.

An epidermal growth factor receptor-targeted and endoplasmic reticulum-localized organic photosensitizer toward photodynamic anticancer therapy

The endoplasmic reticulum (ER), as the largest organelle in eukaryotic cells, plays complex but pivotal roles in multiple intracellular metabolic functions, including biosynthesis, sensing, and signal transduction, especially in proteins folding and post-translation modification. The ER is regarded as a promising target for anticancer therapy. Based on previous tumor-targeted photodynamic therapy (PDT), we chemically modified the phthalocyanine-based photosensitizer molecule with the small molecular anticancer-targeting drug erlotinib and the ER-targetable moiety methyl sulfonamide to develop an advanced photosensitizer EB-ER-Pc that can specifically target the subcellular organelle ER of EGFR-overexpressing cancer cells. The in vitro experiments show that the dual-target photosensitizer EB-ER-Pc can generate ROS in situ in the ER of the tumor target region to induce ER stress, upregulate Ca2+ ion level, and decrease mitochondrial membrane potential (MMP) to mediate cancer cells death and ablation. The results suggest that EB-ER-Pc is a promising candidate for effective photodynamic cancer therapy.