98273-59-7

Basic information

• Product Name: Benzene, 4-broMo-2-iodo-1-Methoxy-
• Synonyms: Benzene, 4-broMo-2-iodo-1-Methoxy-;4-BroMo-2-iodo-1-Methoxybenzene;4-Bromo-2-iodo-1-methoxybenzene, 4-Bromo-2-iodophenyl methyl ether;4-Bromo-2-iodophenyl methyl ether;Anisole, 4-bromo-2-iodo-
• CAS NO: 98273-59-7
• Molecular Formula: C₇H₆BrIO
• Molecular Weight: 312.93041
• Mol File: 98273-59-7.mol
• Article Data: 31

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: Benzene, 4-broMo-2-iodo-1-Methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 4-broMo-2-iodo-1-Methoxy-(98273-59-7)
• EPA Substance Registry System: Benzene, 4-broMo-2-iodo-1-Methoxy-(98273-59-7)

Safety Data

• Hazardous Substances Data: 98273-59-7(Hazardous Substances Data)

Usage

General Description

Benzene, 4-bromo-2-iodo-1-methoxy-, is a chemical compound with the molecular formula C7H6BrIO. It is a derivative of benzene with a 4-bromo-2-iodo-1-methoxy substituent. Benzene, 4-bromo-2-iodo-1-methoxy- is commonly used in chemical synthesis and organic reactions as a reagent or building block. It is also known for its potential applications in pharmaceutical and agrochemical research. The specific properties and uses of benzene, 4-bromo-2-iodo-1-methoxy- make it a valuable compound in the field of organic chemistry and drug development.

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Relevant articles and documents

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Green bromination method

The invention discloses a green bromination method, and belongs to the field of green organic chemistry. Under the conditions of room temperature, opening and neutrality, reaction raw materials are aromatic hydrocarbon, olefin, alkyne, tryptamine, tryptophane and derivatives thereof with different functional groups, a bromine source is MBrx (M is Fe , Fe , Ce and the like, and x is 2-3), and the unique oxidant is H2O2. Brominated alkanes, alkenes, aromatic hydrocarbons, pyrrolo-indolines and furo-indolines and derivatives thereof can be produced. The bromination reaction is carried out by using easily available and cheap reagents (such as FeBr2, CeB3 and H2O2) in the market and the solvent, and the method has the characteristics of mild reaction conditions, wide substrate application range, simple steps, easiness in operation and no need of separation, is a green, environment-friendly and safe bromination reaction method, and has a good application prospect.

Deprotonative Metalation of Methoxy-Substituted Arenes Using Lithium 2,2,6,6-Tetramethylpiperidide: Experimental and Computational Study

The reaction pathways of lithium 2,2,6,6-tetramethylpiperidide (LiTMP)-mediated deprotonative metalation of methoxy-substituted arenes were investigated. Importantly, it was experimentally observed that, whereas TMEDA has no effect on the course of the reactions, the presence of more than the stoichiometric amount of LiCl is deleterious, in particular without an in situ trap. These effects were corroborated by the DFT calculations. The reaction mechanisms, such as the structure of the active species in the deprotonation event, the reaction pathways by each postulated LiTMP complex, the stabilization effects by in situ trapping using zinc species, and some kinetic interpretation, are discussed herein.