98414-56-3

Basic information

• Product Name: 1,3-Bis(1H-1,2,4-triazol-1-yl)-2-propanone
• Synonyms: 1,3-Bis(1H-1,2,4-triazol-1-yl)-2-propanone;Fluconazole Impurity 18
• CAS NO: 98414-56-3
• Molecular Formula: C7H8N6O
• Molecular Weight: 192.17802
• EINECS: -0
• Mol File: 98414-56-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,3-Bis(1H-1,2,4-triazol-1-yl)-2-propanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Bis(1H-1,2,4-triazol-1-yl)-2-propanone(98414-56-3)
• EPA Substance Registry System: 1,3-Bis(1H-1,2,4-triazol-1-yl)-2-propanone(98414-56-3)

Safety Data

• Hazardous Substances Data: 98414-56-3(Hazardous Substances Data)

Usage

Uses

1,3-Bis(1H-1,2,4-triazol-1-yl)-2-propanone, is the intermediate product in the production of F421000, Fluconazole.

Relevant articles and documents

A preparation method of fluconazole

The invention discloses a preparation method of fluconazol and belongs to the field of pharmaceutical chemistry and chemical synthesis. The preparation method comprises the following reaction processes: adopting low-price and easily-available epoxy chloropropane as a raw material to react with 1,2,4-triazole; then performing oxidation by using sodium hypochlorite; and finally, reacting with a prepared 2,4-difluorophenyl magnesium lithium reagent to prepare fluconazol. The invention provides a brand-new synthetic route and a process, the reaction of each step is easy to operate, the process is simple, the use of a reagent with high toxicity, high environmental protection pressure and high price is effectively avoided, the reaction total yield is improved, the product cost is effectively reduced, and large-scale production can be realized more easily.