98453-29-3Relevant articles and documents
E- and Z-Isomerism of 2-Acetylthiophene Oximes
Conde, Santiago,Corral, Carlos,Lissavetzky, Jaime
, p. 301 - 304 (2007/10/02)
A study of the oximation of a number of 2-acetylthiophenes in order to ascertain the validity of contradictory results previously described is reported.The fact that the steric hidrance is smaller in 2-acetylthiophenes unsubstituted at position-3 than in acetylbenzenes allows in these cases the formation of Z-oximes, which even can predominate on the E oximes in the case of a +M substitution at position-5.In the paper is also shown that the E/Z ratio of 2-acetylthiophene oximes can be deduced from 1H-nmr spectrum of the crude reaction mixture.