98769-74-5

Basic information

• Product Name: (R*,R*)-3-Amino-1-(2-ethoxyphenoxy)-1-phenylpropan-2-ol
• Synonyms: (R*,R*)-3-Amino-1-(2-ethoxyphenoxy)-1-phenylpropan-2-ol;3-Amino-1-(2-ethoxyphenoxy)-1-phenylpropan-2-ol
• CAS NO: 98769-74-5
• Molecular Formula: C₁₇H₂₁NO₃
• Molecular Weight: 287.35
• Mol File: 98769-74-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 468.9°C at 760 mmHg
• Flash Point: 237.4°C
• Appearance: /
• Density: 1.149
• Vapor Pressure: 1.35E-09mmHg at 25°C
• Refractive Index: 1.578
• CAS DataBase Reference: (R*,R*)-3-Amino-1-(2-ethoxyphenoxy)-1-phenylpropan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (R*,R*)-3-Amino-1-(2-ethoxyphenoxy)-1-phenylpropan-2-ol(98769-74-5)
• EPA Substance Registry System: (R*,R*)-3-Amino-1-(2-ethoxyphenoxy)-1-phenylpropan-2-ol(98769-74-5)

Safety Data

• Hazardous Substances Data: 98769-74-5(Hazardous Substances Data)

Usage

General Description

"(R*,R*)-3-Amino-1-(2-ethoxyphenoxy)-1-phenylpropan-2-ol" is a chemical compound that belongs to the class of beta-adrenergic receptor agonists. It is commonly used as a bronchodilator to treat conditions such as asthma, bronchitis, and other respiratory disorders. (R*,R*)-3-Amino-1-(2-ethoxyphenoxy)-1-phenylpropan-2-ol works by relaxing the muscles in the airways, making it easier to breathe. It is typically administered through inhalation and is known for its quick onset of action and effectiveness in relieving respiratory symptoms. However, like any medication, it may have potential side effects and contraindications, so it should be used under the supervision of a healthcare professional.

InChI:InChI=1/C17H21NO3/c1-2-20-15-10-6-7-11-16(15)21-17(14(19)12-18)13-8-4-3-5-9-13/h3-11,14,17,19H,2,12,18H2,1H3

Upstream product

• 98769-72-3 (2RS,3RS)-3-(2-ethoxyphenoxy)-3-phenylpropene-1,2-epoxide 
• 104-54-1 3-Phenylpropenol 
• 93853-04-4 (2RS,3RS)-1-amino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropane methanesulfonate 
• 4407-36-7 (2E)-3-phenyl-2-propen-1-ol 
• 98769-71-2 (2RS,3SR)-3-(2-ethoxyphenoxy)-2-mesyloxy-1-(4-nitrobenzoyloxy)-3-phenylpropane 
• 98769-70-1 (2RS,3SR)-3-(2-ethoxyphenoxy)-2-hydroxy-1-(4-nitrobenzoyloxy)-3-phenylpropane 
• 98769-69-8 (2RS,3SR)-3-(2-ethoxyphenoxy)-1,2-dihydroxy-3-phenylpropane 
• 40641-81-4 trans-2,3-epoxy-3-phenylpropan-1-ol 
• 94-71-3 2-Ethoxyphenol 
• 98769-73-4 (2RS,3SR)-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenyl-1-tosyloxypropane 

Downstream Products

• 104968-70-9 (S,S)-reboxetine (S)-mandelate 
• 93886-32-9 (2RS,3RS)-6-<α-(2-ethoxyphenoxy)benzyl>morpholin-3-one 
• 71620-89-8 reboxetine 
• 71620-89-8 (S,S)-reboxetine 
• 105017-38-7 (2R,3R)-reboxetine 
• 635724-55-9 (2S,3S)-2-[α-(2-ethoxyphenoxy)benzyl]morpholine succinate 
• 98819-74-0 N-[(2S,3S)-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropyl]-2-chloroacetamide 
• 1340546-27-1 (2S,3S)-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropylamine benzoate 
• 1340546-25-9 (2R,3R)-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropylamine 
• 98819-73-9 (+)-(2S,3S)-1-amino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropane 
• 93886-32-9 (-)-(2S,3S)-6-<α-(2-ethoxyphenoxy)benzyl>morpholin-3-one 
• 93851-87-7 Reboxetine mesylate 
• 1340546-26-0 (2R,3R)-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropylamine (S)-(-)-camphanate 
• 93852-40-5 (2RS,3SR)-1-chloroacetylamino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropane 

Relevant articles and documents

Commercial synthesis of (S,S)-reboxetine succinate: A journey to find the cheapest commercial chemistry for manufacture

The development of a synthetic process for (S,S)-reboxetine succinate, a candidate for the treatment of fibromylagia, is disclosed from initial scale-up to deliver material for registrational stability testing through to commercial route evaluation and subsequent nomination. This entailed evaluation of several alternative routes to result in what would have been a commercially attractive process for launch of the compound.

Configurational studies on 2-[α-(2-ethoxyphenoxy)benzyl]morpholine FCE 20124

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