99-29-6

Basic information

• Product Name: 2-BROMO-6-CHLORO-4-NITROANILINE
• Synonyms: 2-bromo-6-chloro-4-nitro-benzenamin;2-BROMO-6-CHLORO-4-NITROANILINE;2-CHLORO-4-NITRO-6-BROMOANILINE;6-BROMO-2-CHLORO-4-NITROANILINE;6-Bromo-2-Chloro-4-Nitro Aniline 2-Chloro-4-Nitro-6-Bromo Aniline;2-Bromo-6-chloro-4-nitrobenzenamine;(2-bromo-6-chloro-4-nitro-phenyl)amine
• CAS NO: 99-29-6
• Molecular Formula: C₆H₄BrClN₂O₂
• Molecular Weight: 251.47
• EINECS: 202-745-9
• Product Categories: Intermediates of Dyes and Pigments;Amines;C2 to C6;Nitrogen Compounds;API Intermediate
• Mol File: 99-29-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 176-178 °C(lit.)
• Boiling Point: 344.7 °C at 760 mmHg
• Flash Point: 162.3 °C
• Appearance: /
• Density: 1.909 g/cm³
• Vapor Pressure: 6.47E-05mmHg at 25°C
• Refractive Index: 1.677
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: -3.31±0.20(Predicted)
• BRN: 2372771
• CAS DataBase Reference: 2-BROMO-6-CHLORO-4-NITROANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-6-CHLORO-4-NITROANILINE(99-29-6)
• EPA Substance Registry System: 2-BROMO-6-CHLORO-4-NITROANILINE(99-29-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: II
• Hazardous Substances Data: 99-29-6(Hazardous Substances Data)

Usage

General Description

2-Bromo-6-chloro-4-nitroaniline is a chemical compound with the molecular formula C6H4BrClN2O2. It is a nitroaniline derivative with a bromine atom at the 2 position, a chlorine atom at the 6 position, and a nitro group at the 4 position on the benzene ring. 2-Bromo-6-chloro-4-nitroaniline is used in the synthesis of dyes, pharmaceuticals, and agrochemicals. It is known to be toxic and should be handled with care. It is also a mutagen and can cause irritation to the skin, eyes, and respiratory system. This chemical compound is important in the field of organic chemistry and is used in various industrial processes.

InChI:InChI=1/C6H4BrClN2O2/c7-4-1-3(10(11)12)2-5(8)6(4)9/h1-2H,9H2

Upstream product

• 874-18-0 2-chloro-4,6-dibromoaniline 
• 13296-94-1 2-bromo-4-nitroaniline 
• 121-87-9 2-Chloro-4-nitroaniline 
• 861601-22-1 1-bromo-3-chloro-2,5-dinitro-benzene 
• 7664-41-7 ammonia 
• 95-50-1 1,2-dichloro-benzene 
• 99-54-7 3,4-dichloronitrobenzene 
• 7697-37-2 nitric acid 
• 64-19-7 acetic acid 
• 71757-05-6 2,4-dibromo-6-chloro-N-nitro-aniline 
• 7664-93-9 sulfuric acid 

Downstream Products

• 861613-72-1 acetic acid-(2-bromo-6-chloro-4-nitro-anilide) 
• 73557-65-0 1,2-dibromo-3-chloro-5-nitro-benzene 
• 35754-19-9 3-bromo-4,5-dichloronitrobenzene 
• 219817-43-3 1-bromo-3-chloro-5-nitrobenzene 
• 59709-38-5 C₂₀H₂₀BrClN₄O₆ 
• 1416421-93-6 C₁₄H₃BrClF₃N₄O₂ 
• 1395499-21-4 C₂₉H₁₇BrClN₇O₅ 
• 1359769-50-8 N,N-diallyl-2-chloro-6-(3-furyl)-4-nitroaniline 
• 1359769-48-4 N-allyl-2-chloro-6-(3-furyl)-4-nitroaniline 
• 1359768-89-0 N,N-diallyl-2-chloro-6-(2-furyl)-4-nitroaniline 
• 1359768-88-9 tert-butyl-allyl[2-chloro-6-(2-furyl)-4-nitrophenyl]carbamate 
• 1359768-87-8 N-allyl-2-chloro-6-(2-furyl)-N-methyl-4-nitroaniline 
• 1359768-84-5 N-allyl-2-chloro-6-(2-furyl)-4-nitroaniline 
• 1359768-77-6 2-chloro-6-(2-furyl)-4-nitroaniline 

Relevant articles and documents

Environment-friendly preparation method of 2-chloro-4-nitro-6-bromoaniline

A preparation method of 2-chloro-4-nitro-6-bromoaniline comprises the following steps: (a) carrying out mixed acid nitration on o-dichlorobenzene, and continuing to apply the generated waste acid to anext nitration reaction; (b) purifying the obtained nitration product in an alcohol solvent to obtain 3,4-dichloronitrobenzene, and continuously applying the recovered alcohol solvent to a next purification process; (c) carrying out ammonolysis on the 3,4-dichloronitrobenzene in a water phase by adopting a specific catalyst to prepare o-chloro-p-nitroaniline, and continuously applying the recycled liquid ammonia to a next ammonolysis reaction; and (d) brominating o-chloro-p-nitroaniline in a hydrogen bromide and oxidant system, and recycling brominated waste acid liquid and bromine for a nextbromination reaction. The product obtained by the method is good in yield, high in purity and high in quality; and two waste acids and bromine in the product are recycled, so that the amount of wastewater is reduced. Compared with traditional processes, the method has obvious quality and environmental protection advantages, and has high production safety.

Sodium lauryl sulfate-catalyzed oxidative chlorination of aromatic compounds

Chlorination of commercially important aromatic compounds using sodium chloride as chlorine source and sodium periodate as oxidant in acidic medium catalyzed by sodium lauryl sulfate (SLS) led to the chloro-substituted aromatics in good yields and purity. Addition of sodium lauryl sulfate led to increased chlorination rate, better yield, excellent purity, and better quality of end product. The advantages of the present method are greater yield, excellent purity, and shorter reaction time at room temperature. Also dichlorinated product can be obtained by increasing the amount of sodium chloride and sodium periodate at slightly higher temperature (40C).