99586-65-9

Basic information

• Product Name: 4-Chloropyridine-2-carboxamide
• Synonyms: 4-Chloro-2-picolinamide;4-Chloropyridine-2-carboxamide ,95%;4-Chloropyridine-2-c;2-PyridinecarboxaMide,4-chloro;4-Chloropicolinamide, 2-Carbamoyl-4-chloropyridine;IFLAB-BB F2108-0034;4-CHLOROPICOLINAMIDE;4-CHLORO-PYRIDINE-2-CARBOXYLIC ACID AMIDE
• CAS NO: 99586-65-9
• Molecular Formula: C₆H₅ClN₂O
• Molecular Weight: 156.57
• Product Categories: NULL;blocks;Carboxes;Pyridines;Pyridine series;Pyridine
• Mol File: 99586-65-9.mol
• Article Data: 41

Chemical Properties

• Melting Point: 148-152
• Boiling Point: 298.1 °C at 760 mmHg
• Flash Point: 134.1 °C
• Appearance: Off-white/Solid
• Density: 1.381 g/cm³
• Vapor Pressure: 0.0013mmHg at 25°C
• Refractive Index: 1.588
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 14.49±0.50(Predicted)
• CAS DataBase Reference: 4-Chloropyridine-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloropyridine-2-carboxamide(99586-65-9)
• EPA Substance Registry System: 4-Chloropyridine-2-carboxamide(99586-65-9)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 99586-65-9(Hazardous Substances Data)

Usage

Uses

4-Chloropyridine-2-carboxamide, is a versatile building block used in synthesis of various chemical compounds.

InChI:InChI=1/C6H5ClN2O/c7-4-1-2-9-5(3-4)6(8)10/h1-3H,(H2,8,10)

Upstream product

• 24484-93-3 4-Chloro-pyridine-2-carboxylic acid methyl ester 
• 7664-41-7 ammonia 
• 53750-66-6 4-chloro-pyridine-2-carbonyl chloride 
• 284462-37-9 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide 
• 150009-83-9 3-Amino-2-methoxyquinoline 
• 51727-15-2 4-chloro-2-pyridine carboxylic acid chloride hydrochloride 
• 284462-89-1 4-(2-(N-isopropylcarbamoyl)-pyridin-4-yloxy)aniline 
• 626-61-9 4-Chloropyridine 
• 77287-34-4 formamide 
• 176977-85-8 methyl 4-chloro-2-pyridinecarboxylate hydrochloride 
• 98-98-6 2-Picolinic acid 
• 636-80-6 2-picolinic acid hydrochloride 
• 284462-80-2 4-(4-aminophenoxy)-2-pyridinecarboxamide 
• 327-78-6 4-chloro-3-(trifluoromethyl)phenyl isocyanate 

Downstream Products

• 19798-80-2 2-Amino-4-chloropyridine 
• 757251-54-0 4-(4-amino-3-fluorophenoxy)pyridine-2-carboxyamide 
• 928038-30-6 4-(3-Fluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl] amino }phenoxy)pyridine-2-carboxamide 
• 868736-13-4 4-(4-amino-2,5-difluorophenoxy)picolinamide 
• 868735-84-6 4-(4-amino-2,3-difluorophenoxy)picolinamide 
• 868735-85-7 4-(6-amino-2,3-diflurophenoxy)pyridine-2-carboxamide 
• 952490-94-7 4-(4-benzyloxy-phenoxy)-pyridine-2-carboxylic acid amide 
• 769961-47-9 4-(3-amino-4-hydroxy-phenoxy)-pyridine-2-carboxylic acid amide 
• 952490-72-1 4-(4-hydroxy-3-nitro-phenoxy)-pyridine-2-carboxylic acid amide 
• 952490-71-0 4-(4-hydroxy-phenoxy)-pyridine-2-carboxylic acid amide 
• 284462-79-9 4-(3-aminophenoxy)pyridine-2-carboxamide 
• 868733-71-5 4-(4-amino-2-fluorophenoxy)pyridin-2-carboxamide 
• 757251-55-1 4-(4-amino-2-chlorophenoxy)picolinamide 
• 284462-80-2 4-(4-aminophenoxy)-2-pyridinecarboxamide 

Relevant articles and documents

Preparation method of 2-cyano-4-fluoropyridine

The invention discloses a preparation method of 2-cyano-4-fluoropyridine, which comprises the steps of by using 4-chloropyridine-2-methyl formate as a raw material, carrying out ester ammonolysis reaction, amide dehydration reaction and halogen exchange reaction to prepare the 2-cyano-4-fluoropyridine. The method is simple in synthesis process, mild in reaction condition, high in yield and good inproduct purity; the used raw materials are easy to obtain and low in cost, and the preparation method is suitable for industrial production.

Synthesis method of Tucatinib and intermediate product thereof

The invention discloses a synthesis method of Tucatinib, and the method comprises the following step: carrying out substitution reaction on halate of a compound shown in a formula VI or free alkali thereof serving as a raw material and a compound shown in a formula VII under an alkaline condition to obtain a compound shown in a formula VIII. The raw materials used in the whole synthesis route areeasy to obtain, expensive catalysts are not needed, and the method is suitable for large-scale production and beneficial to industrial production of the Tucatinib.

Transition-metal-free synthesis of primary to tertiary carboxamides: A quick access to prodrug-pyrazinecarboxamide

One-pot expedient and direct carbamoylation of heterocyclics is described. The transformation is realized via direct dehydrogenative aminocarbonylation of heterocyclic compounds under transition-metal-free conditions. This method is regioselective and the protocol is proved to be scalable on a gram scale. Further, the therapeutically useful antitubercular agent pyrazinecarboxamide is successfully synthesized by employing this protocol.