99614-01-4

Basic information

• Product Name: ONDANSETRON HYDROCHLORIDE
• Synonyms: sn307;thyl)-,hydrochloride,hydrate(1:1:2);ondansteron hydrochloride dihydrate;OdansetronHCldihydrate;1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one;Zofran;Zophren;Zudan
• CAS NO: 99614-01-4
• Molecular Formula: C₁₈H₁₉N₃O*ClH
• Molecular Weight: 329.82
• Product Categories: Active Pharmaceutical Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals;Serotonin receptor;Amines;Heterocycles;Inhibitors
• Mol File: 99614-01-4.mol
• Article Data: 8

Chemical Properties

• Melting Point: 178.5-179.5°C
• Boiling Point: 546 °C at 760 mmHg
• Flash Point: 284 °C
• Appearance: white/solid
• Density: 1.27 g/cm³
• Vapor Pressure: 1.47E-12mmHg at 25°C
• Storage Temp.: −20°C
• Solubility: H2O: >5 mg/mL
• PKA: 7.4(at 25℃)
• CAS DataBase Reference: ONDANSETRON HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: ONDANSETRON HYDROCHLORIDE(99614-01-4)
• EPA Substance Registry System: ONDANSETRON HYDROCHLORIDE(99614-01-4)

Safety Data

• Hazard Codes: T,Xi
• Statements: 25-36/37/38
• Safety Statements: 45-37/39-26
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: FE6375500
• HazardClass: 6.1(a)
• PackingGroup: II
• Hazardous Substances Data: 99614-01-4(Hazardous Substances Data)

Usage

Chemical Properties

White to Off-White Solid

Uses

A specific serotonin (5-HT3) receptor antagonist. Antiemetic.

InChI:InChI=1/C18H24N4O.ClH/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17;/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23);1H/t12-,13+,14-;

Upstream product

• 693-98-1 2-methylimidazole 
• 99614-02-5 ondanserton 
• 27387-31-1 9-methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one 
• 51-80-9 bis-(dimethylamino)methane 

Downstream Products

• 99614-02-5 ondanserton 

Relevant articles and documents

IMIDAZOLYL MODULATORS OF 5-HT3 RECEPTORS

The present invention relates to new imidazolyl modulators of 5-HT3 receptors, pharmaceutical compositions thereof, and methods of use thereof.

PROCESS FOR PREPARING 1,2,3,9-TETRAHYDRO-9-METHYL-3-[(2-METHYL-1H-IMIDAZOLE-1-YL)METHYL]-4H-CARBAZOL-4-ONE OR ITS SALT

1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]- 4H-carbazol-4-one or its salt is prepared in high yield by reacting a compound of formula 2 with a compound of formula 3 and a compound of formula 4 in the presence of an acid, an alkylsilylhalide compound or an acylhalide compound, in an solvent, and thus, such an inventive process can be favorably applied to a large-scale mass production thereof.

HIGH PURITY ONDANSETRON HYDROCHLORIDE DIHYDRATE AND PROCESS FOR ITS SYNTHESIS

The invention relates to high purity ondansetron hydrochloride dihydrate containing not more than 0.10 w/w % chemical impurities as well as to the process for its synthesis.