99708-49-3

Basic information

• Product Name: 3-(6-chloropyridazin-3-yl)benzonitrile
• Synonyms: 3-(6-chloropyridazin-3-yl)benzonitrile;3-chloro-6-(3-cyanophenyl)pyridazine
• CAS NO: 99708-49-3
• Molecular Formula: C₁₁H₆ClN₃
• Molecular Weight: 215.64
• Mol File: 99708-49-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(6-chloropyridazin-3-yl)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(6-chloropyridazin-3-yl)benzonitrile(99708-49-3)
• EPA Substance Registry System: 3-(6-chloropyridazin-3-yl)benzonitrile(99708-49-3)

Safety Data

• Hazardous Substances Data: 99708-49-3(Hazardous Substances Data)

Usage

General Description

3-(6-chloropyridazin-3-yl)benzonitrile is a chemical compound with the molecular formula C12H6ClN3. It is a heterocyclic compound containing a pyridazine ring and a benzonitrile group. 3-(6-chloropyridazin-3-yl)benzonitrile is used in organic synthesis and pharmaceutical research as a building block for the synthesis of various biologically active molecules. It may also possess potential biological activities or therapeutic properties, although further research is needed to explore its potential applications. 3-(6-chloropyridazin-3-yl)benzonitrile should be handled and used with caution due to its potential hazards and proper safety measures should be taken when handling it.

Upstream product

• 135034-10-5 3-chloro-6-iodopyridazine 
• 150255-96-2 (3‐cyanophenyl)boronic acid 

Downstream Products

• 1201930-22-4 3-[3-(3-bromobenzyl)-1,2,4-triazolo[4,3-b]pyridazin-6-yl]benzonitrile 
• 1233361-02-8 (2S,4S)-4-(2-{3-[3-(3-cyanophenyl)-6-oxo-6H-pyridazin-1-yl-methyl]phenyl}pyrimidin-5-yloxy)pyrrolidine-2-carboxylic acid 
• 1103506-77-9 3-{1-[3-(5-bromopyrimidin-2-yl)-benzyl]-6-oxo-1,6-dihydro-pyridazin-3-yl}-benzonitrile 
• 1103506-79-1 3-{1-[3-(5-hydroxy-pyrimidin-2-yl)-benzyl]-6-oxo-1,6-dihydro-pyridazin-3-yl}-benzonitrile 
• 1103508-21-9 3-(6-oxo-1-{3-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrimidin-2-yl]-benzyl}-1,6-dihydropyridazin-3-yl)-benzonitrile 
• 52240-08-1 3-(6-oxo-1,6-dihydropyridazin-3-yl)-benzonitrile 
• 93182-14-0 3-(4-hydroxypiperidino)-6-(3-cyanophenyl)pyridazine 

Relevant articles and documents

Novel Triazolo Pyridazine Derivatives and Use Thereof

The present invention relates to a novel triazolo pyridazine derivative or a pharmaceutically acceptable salt thereof, to a pharmaceutical composition for inhibiting c-Met tyrosine kinase activity and a pharmaceutical composition for preventing or treating an abnormal proliferation disorder (hyperproliferative disorder) comprising same as an active ingredient, and to a method for preventing or treating an abnormal proliferation disorder (hyperproliferative disorder) comprising a step of administering a pharmaceutically effective amount of the pharmaceutical composition to a subject in need thereof. The present invention can advantageously be used as a therapeutic agent for various abnormal proliferation disorders such as cancer, psoriasis, rheumatoid arthritis and diabetic retinopathy which are associated with excessive cell proliferation and growth due to irregular kinase activity by effectively suppressing the activity of c-Met tyrosine kinase.

PYRIDAZINONE DERIVATIVES

Compounds of the formula (I), in which Y, R1, R2, R3 and R3′ have the meanings indicated in claim 1, are inhibitors of tyrosine kinases, in particular of Met kinase, and can be employed, inter alia, for the treatment of tumours.