99724-19-3

Basic information

• Product Name: 3-N-Boc-aminopyrrolidine
• Synonyms: 3-(BOC-AMINO)PYRROLIDINE;3-N-BOC-AMINO PYRROLIDINE;3-PYRROLIDINYL-CARBAMIC ACID TERT-BUTYL ESTER;3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE;BOC-(+/-)-3-AMINOPYRROLIDINE;BOC-(+/-)-(3)APYROLIDI;TERT-BUTYL PYRROLIDIN-3-YLCARBAMATE;PYRROLIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER
• CAS NO: 99724-19-3
• Molecular Formula: C₉H₁₈N₂O₂
• Molecular Weight: 186.25
• Product Categories: pharmacetical;Pyrrole&Pyrrolidine&Pyrroline;3-Aminopyrrolidines;3-Aminopyrrolidines (Racemic);Amines;Pyrrolidines
• Mol File: 99724-19-3.mol
• Article Data: 10

Chemical Properties

• Melting Point: 67 °C
• Boiling Point: 286.4 °C at 760 mmHg
• Flash Point: 127 °C
• Appearance: /
• Density: 1.04 g/cm³
• Vapor Pressure: 0.00264mmHg at 25°C
• Storage Temp.: 2-8°C
• Solubility: Soluble in Methanol(almost transparency).
• PKA: 12.37±0.20(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 3-N-Boc-aminopyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-N-Boc-aminopyrrolidine(99724-19-3)
• EPA Substance Registry System: 3-N-Boc-aminopyrrolidine(99724-19-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 99724-19-3(Hazardous Substances Data)

Usage

Uses

(+/-)-3-(Boc-amino)pyrrolidine is the homochiral starting materials utilised in the synthesis of all of the chiral compounds. Reactant in the peptide activated G-protein coupled receptors test.

InChI:InChI=1/C9H18N2O2/c1-9(2,3)13-8(12)11-7-4-5-10-6-7/h7,10H,4-6H2,1-3H3,(H,11,12)/p+1/t7-/m0/s1

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 79286-79-6 (3S)-3-aminopyrrolidine 
• 99735-30-5 N-benzyl-3-(R)-((1,1-dimethylethoxycarbonyl)amino)pyrrolidine 

Downstream Products

• 391903-23-4 N-[1-(3-Amino-4-nitrophenyl)pyrrolidin-3-yl] (tert-butoxy)carboxamide 
• 374725-23-2 [1-(3,3-diphenyl-propyl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester 
• 828928-31-0 [1-(2,2-diphenylethyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester 
• 815618-84-9 4-bromo-3-[3-(tert-butoxycarbonylamino)pyrrolidin-1-yl]-1-chloro-6-(2,4-dimethoxybenzyl)-9-oxo-6,9-dihydro-5H-pyrido[4,3-c]azepine-8-carboxylic acid ethyl ester 
• 351355-02-7 4-(3-tert-butoxycarbonylamino-pyrrolidin-1-yl)-3-chloro-2,5-difluoro-benzoic acid ethyl ester 
• 934394-38-4 N'-[4-(3-tert-butoxycarbonylamino-pyrrolidin-1-yl)-2-(2,4-difluoro-phenylamino)-5-fluoro-benzoyl]-hydrazinecarboxylic acid tert-butyl ester 
• 816424-94-9 rac-tert-butyl [1-({3-[(2,4-difluorophenyl)amino]-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl}carbonyl)pyrrolidin-3-yl]carbamate 
• 185057-49-2 (S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-1-pyrrolidinecarboxylic acid,phenylmethyl ester 
• 888972-36-9 [1-(phenylsulfonyl)-3-pyrrolidinyl]-carbamic acid, 1,1-dimethylethyl ester 
• 485-47-2 indan-1,2,3-trione hydrate 
• 457097-99-3 (3S)-3-(tert-butoxycarbonylamino)-1-(4-fluoro-benzyl)-pyrrolidine 
• 226249-13-4 (R)-1-(4-bromobenzyl)-3-(glycylamino)pyrrolidine 
• 301672-74-2 (+/-)-2-chloro-5-[3-[[(1,1-dimethylethoxy)carbonyl]amino]-1-pyrrolidinyl]-benzoic acid, ethyl ester 
• 301672-85-5 (+/-)-[1-(3-Methyl-4-nitrophenyl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester 

Relevant articles and documents

NAPHTHALENYLOXYPROPENYL DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention discloses novel naphthalenyloxypropenyl derivatives useful for inhibiting the enzyme activity of histone deacetylase, leading effective suppression of cancer cell proliferation

PROCESS FOR PRODUCING 1-ALKOXYCARBONYL NITROGENOUS SATURATED HETEROCYCLIC DERIVATIVE

A method for producing N-protected heterocyclic compounds such as 1-alkoxycarbonyl-3-aminopyrrolidines through position-selective reaction at the nitrogen atom that constitutes the hetero ring of a nitrogen-containing saturated heterocyclic compound having two nitrogen atoms such as 3-aminopyrrolidine. A dialkyl dicarbonate (ROCO-O-COOR) is reacted with a nitrogen-containing saturated heterocyclic compounds having two nitrogen atoms, at pH of from 9 to 14 to obtain a high-purity 1-alkoxycarbonyl nitrogen-containing saturated heterocyclic compound.

Naphthyridine antibacterial agents

Novel naphthyridine-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections.