99765-20-5

Basic information

• Product Name: N-(1,2-Diphenylethyl)-2-benzothiazolamin
• CAS NO: 99765-20-5
• Molecular Weight: 330.453
• Mol File: 99765-20-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(1,2-Diphenylethyl)-2-benzothiazolamin(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1,2-Diphenylethyl)-2-benzothiazolamin(99765-20-5)
• EPA Substance Registry System: N-(1,2-Diphenylethyl)-2-benzothiazolamin(99765-20-5)

Safety Data

• Hazardous Substances Data: 99765-20-5(Hazardous Substances Data)

Upstream product

• 615-20-3 2-chlorobenzo[d][1,3]thiazole 
• 25611-78-3 (R,S)-1,2-diphenylethylamine 
• 136-95-8 2-amino-benzthiazole 
• 103-30-0 (E)-1,2-diphenyl-ethene 

Relevant articles and documents

Benzoxazolamines and Benzothiazolamines: Potent, Enantioselective Inhibitors of Leukotriene Biosynthesis with a Novel Mechanism of Action

A series of benzoxazolamine and benzothiazolamine analogs that inhibit leukotriene (LT) biosynthesis are described.The initial lead, (S)-N-(benzothiazol-2-yl)phenylalanine ethyl ester (5a), was discovered in a screening program for inhibition of Ca-ionophore-A23187-induced LTB4 release in human polymorphonuclear leukocytes (IC50 0.23 μM).Through structural modification, it was determined that hydrophobic substituents in the 5-position and replacement of the phenyl ring of phenylalanine with a cyclohexyl group greatly enhance potency.Several ester bioisosteres that retain potency and enantiomeric selectivity are described.Lead optimization culminated in (S)-N--5-methyl-2-benzoxazolamine (43b), IC50 0.001 μM.The compounds described are not inhibitors of 5-lipoxygenase but, rather, act at the level of arachidonic acid release.