Welcome to LookChem.com Sign In|Join Free

CAS

  • or

99844-02-7

Post Buying Request

99844-02-7 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

99844-02-7 Usage

General Description

4-(4-Methoxyphenyl)pyrimidin-2-amine is a chemical compound with the molecular formula C12H11N3O. It is a pyrimidine derivative with a methoxyphenyl group attached to the 4-position of the pyrimidine ring. 4-(4-METHOXYPHENYL)PYRIMIDIN-2-AMINE is commonly used in the pharmaceutical industry as a building block for the synthesis of various biologically active molecules, particularly for the development of kinase inhibitors. It has also been studied for its potential therapeutic effects in the treatment of cancer, inflammation, and other diseases. The chemical properties and structure of 4-(4-Methoxyphenyl)pyrimidin-2-amine make it a valuable tool for medicinal chemistry research and drug discovery efforts.

Check Digit Verification of cas no

The CAS Registry Mumber 99844-02-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,9,8,4 and 4 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 99844-02:
(7*9)+(6*9)+(5*8)+(4*4)+(3*4)+(2*0)+(1*2)=187
187 % 10 = 7
So 99844-02-7 is a valid CAS Registry Number.
InChI:InChI=1/C11H11N3O/c1-15-9-4-2-8(3-5-9)10-6-7-13-11(12)14-10/h2-7H,1H3,(H2,12,13,14)

99844-02-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(4-METHOXYPHENYL)PYRIMIDIN-2-AMINE

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:99844-02-7 SDS

99844-02-7Downstream Products

99844-02-7Relevant articles and documents

Discovery of coumarin derivatives as potent and selective cyclin-dependent kinase 9 (CDK9) inhibitors with high antitumour activity

Chen, Yadong,Dong, Ruinan,Duan, Chunqi,Huang, Jianhang,Jiang, Fei,Li, Hongmei,Li, Shuwen,Liu, Chenhe,Lu, Tao,Tang, Weifang,Wang, Xinren,Xu, Junyu,Zhang, Tianyi,Zhang, Yanmin,Zhu, Gaoyuan,Zhu, Yuqin

, (2020/05/22)

Specific inhibition of CDK9 is considered a promising strategy for developing effective anticancer therapeutics. However, most of the reported CDK9 inhibitors are still at an early stage of development and lack selectivity against other CDKs. Herein, we discovered coumarin derivative 30i as a potent CDK9 inhibitor with high selectivity (8300-fold over CDK7). Binding mode analysis illustrated that the substituent coumarin moiety is a critical group for CDK9 selectivity by occupying a flexible hinge/αD region, which is sterically hindered in other CDKs. Compound 30i showed excellent cellular antiproliferative activity, moderate pharmacokinetic property and low hERG inhibition. Moreover, 30i significantly induced tumour growth inhibition in a dose-dependent manner without causing an obvious loss of body weight in an MV4-11 xenograft mice model. Altogether, these results suggest that 30i may serve as a potential acute myeloid leukaemia (AML) therapeutics by selectively targeting CDK9.

Synthesis of C5-tethered indolyl-3-glyoxylamide derivatives as tubulin polymerization inhibitors

Guggilapu, Sravanthi Devi,Lalita, Guntuku,Reddy, T. Srinivasa,Prajapti, Santosh Kumar,Nagarsenkar, Atulya,Ramu, Shymala,Brahma, Uma Rani,Lakshmi, Uppa Jaya,Vegi, Ganga Modi Naidu,Bhargava, Suresh K.,Babu, Bathini Nagendra

, p. 1 - 12 (2017/02/05)

A series of C5-tethered Indolyl-3-glyoxylamide derivatives were synthesized and evaluated for their in?vitro cytotoxic activity against DU145 (prostate), PC-3 (prostate), A549 (lung) and HCT-15 (colon) cancer cell lines by employing the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Among all the synthesized compounds, compound 7f displayed cytotoxicity of IC50?=?140?nM towards DU145 cancer cell line. The treatment of DU145?cells with 7f led to inhibition of cell migration ability. Futher, the detailed studies such as acridine orange/ethidium Bromide (AO/EB), DAPI, annexin V-FITC/propidium iodide staining assay suggested that the compound 7f induced apoptosis in DU145?cells. The influence of the cytotoxic compound 7f on the cell cycle distribution was assessed on the DU145?cell line, exhibiting a cell cycle arrest at the G2/M phase (hallmark of tubulin polymerization) and next inhibited tubulin polymerization with IC500.40?μM. Furthermore, the treatment with compound 7f caused collapse of mitochondrial membrane potential and elevated intracellular superoxide ROS levels in DU145?cells. Western blotting was performed to examine the levels of apoptotic proteins (Bcl-2 and Bax); the study confirmed that compound 7f induced apoptosis through apoptosis-related protein expression. Thus, these studies provided a new molecular scaffold for the further development of anticancer agents that target tubulin.

New Entry to a Three-Component Pyrimidine Synthesis by TMS-Ynones via Sonogashira Coupling

Karpov, Alexei S.,Mueller, Thomas J. J.

, p. 3451 - 3454 (2007/10/03)

(Equation presented) TMS-ynones are versatile synthetic equivalents of β-keto aldehydes and can be readily synthesized in an atom-economical fashion by coupling (het)aroyl chlorides and (TMS)-acetylene with only one equiv (!) of triethylamine under Sonogashira conditions. This mild ynone synthesis is also a suitable entry to 2,4-disubstituted pyrimidines in the sense of a one-pot three-component reaction, i.e., a coupling-addition- cyclocondensation sequence.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 99844-02-7