Basic information
- Name:
Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one,5-[3,5-dimethoxy-4-(phosphonooxy)phenyl]-9-[[4,6-O-(1R)-ethylidene-b-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-,(5R,5aR,8aR,9S)-
- Superlist Name:
- Etoposide phosphate
- CAS No.:
117091-64-2
- Molecular Structure:
![Molecular Structure of 117091-64-2 (Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one,5-[3,5-dimethoxy-4-(phosphonooxy)phenyl]-9-[[4,6-O-(1R)-ethylidene-b-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-,(5R,5aR,8aR,9S)-)](http://www.lookchem.com/300w/2010/0617/117091-64-2.jpg)
- Formula:
- C29H33O16P
- Molecular Weight:
- 668.54
- Synonyms:
- Etopophos;Etoposide 4'-phosphate;Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one,5-[3,5-dimethoxy-4-(phosphonooxy)phenyl]-9-[(4,6-O-ethylidene-b-D-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-,[5R-[5a,5ab,8aa,9b(R*)]]-;BMY 40481;Etopofos;
- Density:
- 1.55 g/cm3
- Boiling Point:
- 798.1 °C at 760 mmHg
- Flash Point:
- 263.6 °C
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Chemistry
The molecular formula of etoposide phosphate(117091-64-2) is C29H33O16P,and its formula weight is 668.54.The Molecular Structure is:
The density of etoposide phosphate(117091-64-2) is 1.64 g/cm3 and it has a flash point of 502.7 °C.Besides,its index of refraction is 1.659 and the molar refractivity is 150.12 cm3,Its molar volume is 406.7 cm3 and the polarizability is 59.51 10-24m3.The surface tension of etoposide phosphate(117091-64-2) is 83 dyne/cm and the enthalpy of vaporization is 138.25 kJ/mol.The vapour pressure is 1.57E-35 mmHg at 25°C. In addition,it's IUPAC name is [4-[(5R,5aR,8aR,9S)-9-[(7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[5,6-d][1,3]dioxin-6-yl)oxy]-6-oxo-5a,8,8a,9-tetrahydro-5H-isobenzofurano[5,6-f][1,3]benzodioxol-5-yl]-2,6-dimethoxy-phenyl] dihydrogen phosphate. Its synonyms is as follows:ETOPOPHOS;ETOPOSIDE PHOSPHATE;ETOPOSIDE PHOSPHONATE;ETOPOSIDE PHOSPHONATE,ETOPOPHOS;Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5-[3,5-dimethoxy-4-(phosphonooxy)phenyl]-9-[[4,6-O-(1R)-ethylidene-b-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-, (5R,5aR,8aR,9S)-;ETOPOSIDEPHOSPHATE,ETOPOPHOS .Its appearance is white solid.
Uses
Etoside phosphate(117091-64-2) is used as a form of chemotherapy for malignancies such as Ewing's sarcoma, lung cancer, testicular cancer, lymphoma, non-lymphocytic leukemia, and glioblastoma multiforme. It is often given in combination with other drugs. Sometimes it is also used in a conditioning regimen prior to a bone marrow or blood stem cell transplant.Its chemical make-up derives from podophyllotoxin,which is a toxin found in the American Mayapple.
Specification
Freezer (-20°C). Protect from light and moisture. Following
reconstitution, aliquot and freeze (-20°C). This product is stable for 3
years as supplied. Aqueous stock solutions are stable for up to 3
months at -20°C.