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Basic information

  • Name:

  • Ketoprofen

  • CAS No.:

  • 22071-15-4

  • Formula:
  • C16H14O3
  • Synonyms:
  • 3-Benzoyl-alpha-methylbenzeneacetic acid;Epatec;Oruvail;Orudis;Ketoprofen (JP14/USP);2-(3-Benzoylphenyl)propionic acid;3-Benzoylhydratropic acid;Profenid;Benzeneacetic acid,3-benzoyl-R-methyl-;LAcide (benzoyl-3-phenyl)-2-propionique;Alrheumate;m-Benzoylhydratropic acid;ISO-K;Orudis (TN);

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Chemistry

Molecular structure of Ketoprofen (CAS NO.22071-15-4) is:

Product Name: Ketoprofen
CAS Registry Number: 22071-15-4
IUPAC Name: 2-(3-benzoylphenyl)propanoic acid
Molecular Weight: 254.28056 [g/mol]
Molecular Formula: C16H14O3
XLogP3: 3.1
H-Bond Donor: 1
H-Bond Acceptor: 3 
EINECS: 244-759-8
Melting Point: 93-96 °C
Surface Tension: 49.7 dyne/cm
Density: 1.198 g/cm3
Flash Point: 228.8 °C
Enthalpy of Vaporization: 72.41 kJ/mol
Boiling Point: 431.3 °C at 760 mmHg
Vapour Pressure: 3.32E-08 mmHg at 25°C
Product Categories: Pharmaceutical;Active Pharmaceutical Ingredients;APIs;Intermediates & Fine Chemicals;Pharmaceuticals;Lipid signaling

Uses

 Ketoprofen (CAS NO.22071-15-4) is a common NSAID, antipyretic, and analgesic used in horses and other equines. It is also used as a mild painkiller in smaller animals, generally following surgical procedures. It is most commonly used for muscoskeletal pain, joint problems, and soft tissue injury, as well as laminitis. It does not treat the underlying problem, nor does it speed the healing process. It is also used to control fevers and prevent endotoxemia. However, they may mask the symptoms of the underlying problem, and therefore make diagnosis more difficult for a veterinarian.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo unreported 300mg/kg/15D- (300mg/kg) BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES

BEHAVIORAL: HEADACHE

GASTROINTESTINAL: NAUSEA OR VOMITING		 New England Journal of Medicine. Vol. 300, Pg. 796, 1979.
guinea pig LD50 intravenous 450mg/kg (450mg/kg)   Journal de Pharmacologie. Vol. 2, Pg. 259, 1971.
guinea pig LD50 oral 1300mg/kg (1300mg/kg)   Journal de Pharmacologie. Vol. 2, Pg. 259, 1971.
human TDLo oral 714ug/kg (0.714mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING Journal of Clinical Pharmacology. Vol. 24, Pg. 486, 1984.
man TDLo oral 5714ug/kg (5.714mg/kg) LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL" Clinical Rheumatology. Vol. 10, Pg. 215, 1991.
mouse LD50 intraperitoneal 300mg/kg (300mg/kg)   European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 11, Pg. 7, 1976.
mouse LD50 intravenous 500mg/kg (500mg/kg)   Journal de Pharmacologie. Vol. 2, Pg. 259, 1971.
mouse LD50 oral 360mg/kg (360mg/kg)   Polish Journal of Pharmacology and Pharmacy. Vol. 38, Pg. 107, 1986.
mouse LD50 subcutaneous 550mg/kg (550mg/kg)   Journal de Pharmacologie. Vol. 2, Pg. 259, 1971.
rat LD50 intraperitoneal 80mg/kg (80mg/kg)   Drugs in Japan Vol. 6, Pg. 265, 1982.
rat LD50 intravenous 350mg/kg (350mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 9, Pg. 222, 1978.
rat LD50 oral 62400ug/kg (62.4mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 280, 1984.
rat LD50 rectal 84mg/kg (84mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE

GASTROINTESTINAL: PERITONITIS		 Journal of Toxicological Sciences. Vol. 6, Pg. 209, 1981.
rat LD50 subcutaneous 100mg/kg (100mg/kg)   Journal de Pharmacologie. Vol. 2, Pg. 259, 1971.
women TDLo oral 11mg/kg/12H-I (11mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

CARDIAC: PULSE RATE

SKIN AND APPENDAGES (SKIN): SWEATING: OTHER		 Journal of Clinical Pyschopharmacology. Vol. 19, Pg. 95, 1999.
women TDLo oral 80mg/kg/10D-I (80mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" British Medical Journal. Vol. 292, Pg. 97, 1986.

Safety Profile

Hazard Codes: ToxicT
Risk Statements: 25-36/37/38-23/24/25 
R25 :Toxic if swallowed. 
R36/37/38:Irritating to eyes, respiratory system and skin. 
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
Safety Statements: 26-45-36/37/39 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
RIDADR: 2811
RTECS: UE7570000
HazardClass: 6.1(b)
PackingGroup: III

Specification

 Ketoprofen , its cas register number is 22071-15-4. It also can be called 2-(3-Benzoylphenyl)propionic acid ; 2-(meta-Benzoylphenyl) propionic acid ; Alrheumat ; Benzeneacetic acid, 3-benzoyl-alpha-methyl- ; Propionic acid, 2-(3-benzoylphenyl)- ; Actron ; Alrheumun ; Aneol .It is a white crystalline solid.

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