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l-Methadone
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Name

l-Methadone

 EINECS N/A
CAS No. 125-58-6 Density 1.009g/cm3
PSA 20.31000 LogP 4.29200
Solubility N/A Melting Point 99°C
Formula C21H27 N O Boiling Point 423.7°Cat760mmHg
Molecular Weight 309.451 Flash Point 126.5°C
Transport Information N/A Appearance N/A
Safety Poison by ingestion, subcutaneous, and intraperitoneal routes. Experimental reproductive effects. Mutation data reported. Caution: Abuse leads to habituation or addiction. When heated to decomposition it emits toxic fumes of NOx. See also METHADONE HYDROCHLORIDE. Risk Codes N/A
Molecular Structure Molecular Structure of 125-58-6 (R(-)-METHADONE HYDROCHLORIDE OPIOID AGON IST) Hazard Symbols N/A
Synonyms

3-Heptanone,6-(dimethylamino)-4,4-diphenyl-, (R)-; 3-Heptanone,6-(dimethylamino)-4,4-diphenyl-, L- (8CI); (-)-Methadone; (6R)-Methadone;(R)-Methadone; D-(-)-Methadone; Levomethadone; Levothyl; Polamivet;R-(-)-Methadone; l-Methadone; l-Polamivet

Article Data 8

l-Methadone Chemical Properties

Molecular Structure of l-Methadone (CAS NO. 125-58-6):

IUPAC Name: (6R)-6-(Dimethylamino)-4,4-diphenylheptan-3-one 
Molecular Formula: C21H27NO
Molecular Weight: 309.445180 g/mol
XLogP3: 3.9
H-Bond Donor: 0
H-Bond Acceptor: 2
Canonical SMILES: CCC(=O)C(CC(C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2
Isomeric SMILES: CCC(=O)C(C[C@@H](C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2
InChI: InChI=1S/C21H27NO/c1-5-20(23)21(16-17(2)22(3)4,18-12-8-6-9-13-18)19-14-10-7-11-15-19/h6-15,17H,5,16H2,1-4H3/t17-/m1/s1
InChIKey: USSIQXCVUWKGNF-QGZVFWFLSA-N
Index of Refraction: 1.538
Molar Refractivity: 95.91 cm3
Molar Volume: 306.4 cm3
Surface Tension: 37.1 dyne/cm
Density: 1.009 g/cm3
Flash Point: 126.5 °C
Enthalpy of Vaporization: 67.8 kJ/mol
Boiling Point: 423.7 °C at 760 mmHg
Vapour Pressure: 2.2E-07 mmHg at 25 °C
Water Solubility: 48.48 mg/L at 25 °C
BRN of l-Methadone (CAS NO. 125-58-6): 3213668

l-Methadone Toxicity Data With Reference

1.    

dni-rat:tes 50 µmol/L

     BCPCA6    Biochemical Pharmacology. 27 (1978),123.
2.    

oms-rat:tes 50 µmol/L

     BCPCA6    Biochemical Pharmacology. 27 (1978),123.
3.    

orl-mus LD50:97 mg/kg

     JPETAB    Journal of Pharmacology and Experimental Therapeutics. 198 (1976),340.
4.    

ipr-mus LD50:32 mg/kg

     BJPCAL    British Journal of Pharmacology and Chemotherapy. 9 (1954),280.
5.    

scu-mus LD50:26,500 µg/kg

     MEXPAG    Medicina Experimentalis. 2 (1960),323.

l-Methadone Safety Profile

Poison by ingestion, subcutaneous, and intraperitoneal routes. Experimental reproductive effects. Mutation data reported. Caution: Abuse leads to habituation or addiction. When heated to decomposition it emits toxic fumes of NOx. See also METHADONE HYDROCHLORIDE.

l-Methadone Specification

  l-Methadone with cas registry number of 125-58-6 is also known as (-)-Methadone ; (6R)-Methadone ; (R)-6-(Dimethylamino)-4,4-diphenyl-3-heptanone ; (R)-6-(Dimethylamino)-4,4-diphenyl-3-hetpanone ; 3-14-00-00278 (Beilstein Handbook Reference) ; L-6-(Dimethylamino)-4,4-diphenyl-3-heptanone ; L-Polamidon ; Levometadona ; Levometadona [INN-Spanish] ; Levomethadone ; Levomethadone [INN] ; Levomethadonum ; Levomethadonum [INN-Latin] ; Levothyl ; Polamivet ; l-Polamivet ; (-)-(R)-6-(Dimethylamino)-4,4-diphenyl-3-heptanone ; 3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-, L- ; 3-Hetpanone, 6-(dimethylamino)-4,4-diphenyl-, (R)- (9CI) .