*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : QC8640000
CHEMICAL NAME : Morphinan-3,6-alpha-diol,
7,8-didehydro-4,5-alpha-epoxy-17-methyl-, 17-oxide
CAS REGISTRY NUMBER : 639-46-3
LAST UPDATED : 199306
DATA ITEMS CITED : 3
MOLECULAR FORMULA : C17-H19-N-O4
MOLECULAR WEIGHT : 301.37
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* Genomorphin
* Genomorphine
* Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl-,
(5-alpha,6-alpha)-, 17-oxide
* Morphine oxide
* Morphine N-oxide
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >5300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great
Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
Volume(issue)/page/year: 21,668,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 820 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great
Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
Volume(issue)/page/year: 21,668,1969
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 22 gm/kg/22D-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great
Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
Volume(issue)/page/year: 21,668,1969
*** END OF RECORD ***
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MORPHINE N-OXIDE