apoptotic, antiproliferative and antiangiogenic agent, in vitro and in vivo ; acts via an estrogen receptor-independent mechanism. induces p53-induced apoptosis via two pathways: activation of p38 and nf- κ b; and activation of jnk and ap-1 leading to bcl-2 phosphorylation. also upregulates death receptor 5 and binds to tubulin, inhibiting its assembly.
usage:
2-methoxyestradiol (cas.362-07-2) is a natural metabolite which is devoid of estrogenic activity. it is inhibits cell proliferation and angiogenesis.