362-07-2 2-METHOXYESTRADIOL CAS NO.362-07-2

2-methoxyestradiol basic information

product name: 2-methoxyestradiol

synonyms: 2,3,17beta-trihydroxy-1,3,5[10]-estratriene 2-methyl ether;3,17beta-dihydroxy-2-methoxy-1,3,5[10]-estratriene;2-methoxy-3,17beta-dihydroxyestra-1,3,5(10)-triene;2-methoxy-estra-1,3,5(10)-triene-3,17beta-diol;2-methoxyestradiol;1,3,5(10)-estratriene-2,3,17beta-triol 2-methyl ether;1,3,5[10]-estratriene-2,3,17-triol 2-methyl ether;1,3,5(10)-estratrien-2,3,17-beta-triol 2-methyl ether

cas: 362-07-2

mf: c19h26o3

mw: 302.41

einecs:

product categories: intermediates & fine chemicals;metabolites & impurities;pharmaceuticals;steroids;inhibitor;2-me2;isolabel;inhibitors

mol file: 362-07-2.mol

2-methoxyestradiol structure

2-methoxyestradiol chemical properties

melting point 188-190°c

storage temp. −20°c

solubility dmso: 10 mg/ml

form crystalline

color light yellow

cas database reference 362-07-2(cas database reference)

safety information

hazard codes t,xi,n

risk statements 23/24/25-36/37/38-48-61-60-46-45-51/53

safety statements 22-26-36/37/39-45-53-36-61

ridadr un 3077 9/pg 3

wgk germany 3

rtecs kg7537500

msds information

provider language

sigmaaldrich english

2-methoxyestradiol usage and synthesis

chemical properties off-white solid

usage a natural metabolite of 17estradiol which is devoid of estrogenic activity. inhibits cell proliferation and angiogenesis. binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule a

usage a natural metabolite of 17β-estradiol which is devoid of estrogenic activity. inhibits cell proliferation and angiogenesis. binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly

usage 2-methoxyestradiol is a tubulin polymerization inhibitor and also decreases hif-1 activity.

usage 2-methoxyestradiol depolymerizes microtubules and blocks hif-1α nuclear accumulation and hif-transcriptional activity. phase 2.

usage 2-methoxy 17β-estradiol is a natural metabolite of 17β-estradiol which is devoid of estrogenic activity. inhibits cell proliferation and angiogenesis. 2-methoxy 17β-estradiol binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly and function.

biological activity apoptotic, antiproliferative and antiangiogenic agent, in vitro and in vivo ; acts via an estrogen receptor-independent mechanism. induces p53-induced apoptosis via two pathways: activation of p38 and nf- κ b; and activation of jnk and ap-1 leading to bcl-2 phosphorylation. also upregulates death receptor 5 and binds to tubulin, inhibiting its assembly.