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Allantoin CAS NO.97-59-6

Min.Order Quantity:
1 Gram
Purity:
98%
Port:
China Main Ports
Payment Terms:
L/C,T/T,MoneyGram,Other

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Product Details

Keywords

  • Allantoin
  • 97-59-6
  • manufacturer , better price with good quality

Quick Details

  • ProName: Allantoin
  • CasNo: 97-59-6
  • Molecular Formula: C4H6N4O3
  • Appearance: White Solid
  • Application: Organic Chemistry
  • DeliveryTime: Within 7 days
  • PackAge: Depended
  • Port: China Main Ports
  • ProductionCapacity: 300 Kilogram/Month
  • Purity: 98%
  • Storage: KEEP COLD
  • Transportation: BY SEA OR AIR
  • LimitNum: 1 Gram

Superiority

allantoin chemical properties
mp 230 °c (dec.)(lit.)
fp 230-234°c
storage temp. refrigerator
decomposition 230-234 ºc
merck 14,258
brn 102364
stability: stable. incompatible with strong oxidizing agents.
cas database reference 97-59-6(cas database reference)
nist chemistry reference urea, (2,5-dioxo-4-imidazolidinyl)-(97-59-6)
epa substance registry system urea, (2,5-dioxo-4-imidazolidinyl)- (97-59-6)
safety information
hazard codes xn,xi
risk statements 22-36/37/38
safety statements 22-24/25-36-26
wgk germany 1
rtecs yt1600000
hs code 29332100
hazardous substances data 97-59-6(hazardous substances data)
msds information
provider language
(2,5-dioxo-4-imidazolidinyl)urea english
acros english
sigmaaldrich english
alfa english
allantoin usage and synthesis
anti-inflammatory analgesic effects allantoin has anti-inflammatory analgesic effects, but it also has a weak partial paralysis effect, can effectively reduce stimuli of stimulus, can be used as a skin protectant and anti-irritant, can reduce skin irritation of cosmetic ingredients, china food and drug administration rank it as the first kind efficient active ingredient of skin care agent, now has been widely used in many products such as shampoo, sunscreen products, creams and lotions, shaving creams and oral care products.
chemical properties colorless crystalline powder. melting point is 238-240 ℃ (decomposition). can be dissolved in hot water, hot alcohol and dilute sodium hydroxide solution, slightly soluble in water and alcohol, almost insoluble in ether and chloroform. odorless, tasteless. in dry air is stable, prolonged boiling in the water. or strong base will be destroyed. ph of saturated aqueous solution is 5.5.
the above information is edited by the chemicalbook of liu yujie.
application 1. allantoin can promote skin cell growth and rapid wound healing. used as anti-ulcer drug, mixed with dry aluminum hydroxide gel, for gastrointestinal ulcers and inflammation. the product can soften keratin, making the skin retain moisture, moist and soft, is special effects of additive in cosmetic. allantoin and its derivatives are the quality improver and additive of many household chemical products. allantoin protein may be formulated anti-irritant, anti-dandruff, cleaning and wound healing scalp preparations, making hair soft, shiny and elastic. the product is an amphoteric compound, can bind to a variety of material form double salts, with dark, antiseptic, analgesic, deodorant, anti-oxidation effect, and therefore is household chemical products, additives of cosmetics such as freckle cream, acne solution, shampoo , soap, toothpaste, shaving lotion, convergence liquid and antiperspirant deodorant detergent. allantoin also is a biochemical reagents.
2. for the roles such as skin care, oral products, anti-allergy, the treatment of skin ulcers promote wound healing.
3. widely used in treatment of a variety of skin ulcers and trauma and additives of nutritional cosmetics.
production methods allantoin presents in the sheath cyst fluid, fetal urine and some of the plants. however, the cost extracted allantoin from these substances is too high. currently synthesis methods of allantoin are: potassium permanganate oxidation uric acid method: dichloroacetic acid and urea heated to synthesize allantoin; direct condensation method of glyoxylic acid and urea.
1. technological process of dichloroacetic acid and urea as raw materials is as follows: the sodium methoxide solution and methanol were added into the reaction tank, and heated to 40-50 ℃, slowly dropwise added dichloroacetic acid, after added and reflux reaction for 2 h. cooled to room temperature, filtered, washed with methanol and the filtrate was combined, washed, added methanol solution of sodium dimethoxyethane. the solution was reduced to dryness under reduced pressure , 2.8 portion of hydrochloric acid was added,heated and stirred into a paste in a water bath. then heated to 90 ℃, and then cooled to about 10 ℃, filtered, 0.25 portion of hydrochloric acid and urea was added into , dissolved by heated, reacted at 80 ℃ for 2 h. cooled and crystallization, and then maintained at 0 ℃ for above 3 h, centrifugation, washed ,spin-dried, dried to crude product. after the crude product was used 15 times of the water to recrystallize, allantoin was obtained. as for the dichloroacetic acid, the total yield was 30.3%.
2. the direct condensation of glyoxylic acid and urea (glyoxylate derived by oxidation of glyoxal) operation example: (1) oxidation was in 500 ml four-hole boiling flask equipped with mechanical stirrer, condenser, thermometer and dropping funnel, added 193 g (1 mol) 30% glyoxal aqueous solution, controlled the internal temperature at 40 ± 2 ℃ and stirred to dropwise add 135.5 g ( 1 mol) 45% nitric acid, after addition, continued to stir at this temperature and reacted for 2-3 h, until reddish brown oxidation no longer escaped, the reaction solution was blue-green and immediately disappeared. replaced by simple distillation apparatus, at about 2.76 kpa, the outside temperature did not exceed 60 ℃ and about 125 g water was evaporated, concentrate solution was standing overnight at room temperature, oxalic acid crystals were precipitated (dried to get 19 g, together 0.21 mol), concentration was 39% ). continue to stir and react for about 8h at an internal temperature of 40 ± 2 ℃, the oxidation reaction was completed. (2) condensation in 500 ml three-hole boiling flask equipped with mechanical stirrer, condenser and thermomete, above 150 g glyoxylic acid aqueous solution was added, added 170 g (2.83 mol) urea and 23.3 g of concentrated hydrochloric acid, heated to an internal temperature of 80 ℃ under stirring. after about 15min urea was dissolved, the reaction solution was transparent, approximately another 30-45 min, the reactant appeared white cloudy, white precipitate was gradually increased, stirred at an inner temperature of 80 ℃ for 1 h, heating was stopped and the reactant was cooled to room temperature, the white precipitate was collected on a buchner funnel, precipitated with cold water several times, obtained crude product of allantoin. used 1000 ml distilled water to recrystallize. 60-63% white fine crystalline allantoin was obtained, melting point was 236 ℃ (decomposition). calculated by glyoxal, the theoretical yield of allantoin was 38-40% (weight yield was 103-108%).
chemical properties white solid
usage wound healing agent
usage diuretic
usage vulnerary; debriding agent. purine metabolite via the uric acid pathway.
allantoin preparation products and raw materials
raw materials urea-->glyoxal-->glyoxylic acid-->dichloroacetic acid

Details

henan sunlake enterprise corporation is located in henan province, the central plain of china , which enjoys favorable geogeaphical position and convenient transportion. the comany was established in june 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .
sunlake is a professional manufacturer engaged in producing and selling chemicals,including organic & inorganic chemicals , pigments & dyestuffs , water treatment chemicals , food & feed additives and others . these products have been being well exported to europe , southeast asia , the middle east , africa , south america and some other countries and areas.
we sincerely welcome foreign friends to visit our plant for cooperation. with the idea of "quality first,credit priority, excellent service", we are highly acknowledged by customers for good quality and competitive price. more importantly , the company has a strong r & d team who are professional engineers and scholars with ph. d. .so we are confident to serve you better with our high - quality products and professional team.
we are taking great efforts to provide our customers with demanded goods and professional services, continuously improve our core ability of competition and get the momentum for sustainable development ,which finally makes us being a reliable and professional supplier in international market.
we welcome any inquiries from all customers of the world, and sincerely hope to cooperate with you for a brilliant future!
our advantages:
i). we have abundant professional production experience.
ii). we have our own chemical factory.
iii). sample is free of charge.
iv). reasonable price, excellent quality & attentive service
v). prompt reply: we can reply your inquiry and email within 24 hours.
vi). fast delivery: the delivery time is about 10-20 days after receiving the deposit.
vii). we have passed the lfgb, sgs, stc, hsl and some other tests.
viii). we have a unity cooperation team.
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