China (Mainland) 
tianeptine sodium salt
is a drug used primarily in the treatment of major depressive disorder, although it may also be used to treat asthma or irritable bowel syndrome. chemically it is a tricyclic antidepressant (tca), but it has different pharmacological properties than typical tcas as recent research suggests that tianeptine produces its antidepressant effects through indirect alteration of glutamate receptor activity (i.e., ampa receptors and nmda receptors) and release of bdnf, in turn affecting neural plasticity.
tianeptine has antidepressant and anxiolytic (anti-anxiety) properties with a relative lack of sedative, anticholinergic and cardiovascular adverse effects, thus suggesting it is particularly suitable for use in the elderly and in those following alcohol withdrawal; such persons can be more sensitive to the adverse effects of psychotropic drugs. recent results indicate possible anticonvulsant (anti-seizure) and analgesic (painkilling) activity of tianeptine via immediate or downstream modulation of adenosine a1 receptors (as the effects could be experimentally blocked by antagonists of this receptor).
|
test |
specification |
result |
|
appearance |
light yellow to off-white crystals |
off-white crystals |
|
identification |
1-hnmr: consistent with the standard |
conforms |
|
ir: the ir absorption spectrum of the sample must be concordant with test standard. |
conforms |
|
|
hplc: the hplc spectrum of the sample must be concordant with the standard substance. |
conforms |
|
|
residue on ignition |
nmt 0.2% |
0.02% |
|
solubility |
soluble in water and methanol |
conforms |
|
water |
nmt 5.0% |
0.28% |
|
heavy metals |
nmt 20ppm |
5ppm |
|
related substance |
any other impurity: nmt 0.10% |
0.05% |
|
total impurities: nmt 0.5% |
0.17% |
|
|
residual solvents |
acetone: nmt 0.5% |
n.d. |
|
dichloromethane: nmt 0.06% |
confirms |
|
|
assay(by hplc) |
99.0% |
99.83% |
|
storage |
store in a tightly closed container in a cool and dry place, below 20ºc. |
|
|
conclusion |
confirm to enterprise standard |
|
|
product name: |
tianeptine sodium salt |
|
synonyms: |
tianeptine sodium;tianeptine sodium salt;sodium 7-((3-chloro-6,11-dihydro-6-methyldibenzo(c,f)(1,2)thiazepin-11-yl)amino)heptanoate s,s-dioxide;7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid s,s-dioxide sodium salt;s-1574;stablon;7-[(3-chloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepine-11-yl)amino]heptanoic acid s,s dioxide sodium salt;sodium 7-((3-chloro-6,11-dihydro-6-methyldibenzo |
|
cas: |
30123-17-2 |
|
mf: |
c21h24cln2nao4s |
|
mw: |
458.93 |
|
einecs: |
250-059-3 |
function:
tianeptine is antidepressant. the animal has: the hippocampus pyramidal cells increased spontaneous activity, and accelerating its function was inhibited after recovery; increase in cortical and hippocampal neurons at sites of 5- serotonin reuptake. tianeptine without following adverse effects: sleep and alertness; cardiovascular system; cholinergic system ( without anticholinergic symptoms ); drug craving.
application
chemicals of the central nervous system drugs.
|
|
1. quality assurance |