Artemisinin CAS NO.63968-64-9

product introduction

artemisinin is a kind of malaria treatment effect is the best medicine, is extracted from chinese medicine artemisia annua had half as many oxygen groups of terpene lactones drugs, efficient, quick, clear heat has soared, annealing heat, kill parasite, low toxicity, etc, are all over the world use artemisinin-based combination therapy (act) for the treatment of malaria curative effect more than 90%, has been widely used in the treatment of malaria. it has a strong and rapid killing effect on the malaria parasite red, and can quickly control the clinical onset and symptoms. at the same time, chicken coccidiosis, pig with red cell body disease, toxoplasmosis, yin deficiency fever, hot and humid jaundice, vivax malaria, falciparum malaria, cerebral malaria and chloroquine malaria have prominent curative effects.

artemisinin was first developed by chinese scientists, from the folk treatment of malaria in china herbal medicine effective monomer separated a. annua, one of the major countries of this raw material plant growth in china, research needs originated in the sixties of the vietnam war, malaria parasites have developed resistance to the specific chloroquine, at that time many soldiers died in the war, but to die from malaria.

since artemisinin resistance has emerged in the cambodia-thailand border region, the world health organization has advocated the use of compound agents rather than monomers. in this environment, the world's first on the basis of the artemisinin drugs of antimalarial drugs - compound artemether developed in china, but as a result of chinese medicine enterprises for the importance of intellectual property rights is not enough, only novartis has led to the current world, the world health organization approved by the compound artemether rights abroad, at cost will provide to the who, the drug has won widespread praise of the international community, in the post can only play the role of an api producer in china.

pharmacological action:

artemisinin is a drug that has been extracted from the leaves of the plant. the rat parasites within red period ultrastructure, mainly the parasite membrane structural changes in the system, the drug acts on the first food vacuole membrane, membrane, mitochondria, endoplasmic reticulum, in addition to the nuclear chromatin has a certain influence. the function of artemisinin is mainly interfered with the function of the membrane - mitochondria. may be artemisinin on food vacuole membrane, thereby blocking the earliest stage of nutritional intake, parasites fast amino acids starvation, quickly autophagy bubble formation, and the insect body, continuously make the malaria parasite lose a lot of cytoplasm and death. in vitro culture of plasmodium falciparum is also indicated by the uptake of tritium labeled isoleucine, which may inhibit protozoa synthesis.