Bulk offering first-class Ibrutinib 936563-96-1 supplier CAS NO.936563-96-1

bulk offering first-class ibrutinib 936563-96-1 supplier

raw pharmaceutical 99.9% purity ibrutinib for treat b cell cancers cas 936563-96-1

ibrutinib (imbruvica) is a small molecule drug that binds permanently to a protein, bruton's tyrosine kinase (btk), that is important in b cells; the drug is used to treat b cell cancers like mantle cell lymphoma, chronic lymphocytic leukemia, and waldenström's macroglobulinemia, a form of non-hodgkin's lymphoma.

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ibrutinib is a highly selective bruton’s tyrosine kinase (btk) irreversible inhibitor.pci-32765 (ibrutinib) is a selective and irreversible pyrrolopyrimidine-based inhibitor of btk with ic50 of 0.5 nm. [1] pci-32765 binds irreversibly to cys-481 in btk and thus is only active with other kinases with such a modifiable cysteine residue. in dohh2 cells, in which the bcr pathway can be activated by anti-igg, pci-32765 inhibits autophosphorylation of btk (ic50, 11 nm), btk's physiological substrate, plcg (ic50, 29 nm), and downstream erk (ic50, 13 nm).

ibrutinib is used to treat chronic lymphocytic leukemia, waldenstrom's macroglobulinemia, and as a second-line treatment for mantle cell lymphoma, marginal zone lymphoma, and chronic graft vs host disease.

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