Henan Tianfu Chemical Co., Ltd.
Country: China (Mainland)
Year Established: 2006
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Business type: Lab/Research institutions
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C10H14O Carvacrol 499-75-2 CAS NO.499-75-2

Min.Order Quantity:: 1 Metric Ton

Purity:: 99.5%

Port:: Any port of China

Payment Terms:: L/C,T/T,

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Product Details

Keywords

Carvacrol
499-75-2
C10H14O

Quick Details

ProName: C10H14O Carvacrol 499-75-2
CasNo: 499-75-2
Molecular Formula: C10H14O
Appearance: Powder
Application: 499-75-2 ...
DeliveryTime: by air
PackAge: Aluminium Foil Bag and Paper Drum
Port: Any port of China
ProductionCapacity: 100 Metric Ton/Day
Purity: 99.5%
Storage: 1MT
Transportation: By Sea/Air/DHL
LimitNum: 1 Metric Ton
Grade: Industrial Grade,Food Grade,Pharma Gra...

Superiority

our company was built in 2009 with an iso certificate.in the past 5 years, we have grown up as a famous fine chemicals supplier in china and we had established stable business relationships with samsung,lg,merck,thermo fisher scientific and so on.our main business covers the fields below:

1.noble metal catalysts (pt.pd...)

2.organic phosphine ligands (tert-butyl-phosphine.cyclohexyl-phosphine...)

3.oled intermediates (fluorene,carbazole,boric acid...)

4.customs synthesis

our advantage:

1. higest quality and good package

2.fast delivery

3.better payment term

4.fast response to customer within 6 hours

5.good business credit in europe ,us ,japan ,korea

anyway ,if you need any chemicals from china ,henan tianfu can help you

Details

carvacrol basic information

artificial flavor chemical properties content analysis toxicity toxicity usage limit standard for maximum allowable amount chemical properties application preparation category toxic classification acute toxicity flammability and hazardous characteristics storage and transportation characteristics extinguishing agent

product name:	carvacrol
synonyms:	1-hydroxy-2-methyl-5-isopropylbenzene;2-hydroxy-1-methyl-4-(1-methylethyl)benzene;2-hydroxy-4-(2-propyl)toluene;2-hydroxy-p-cymen;2-methyl-5-(1-methylethyl)-pheno;2-para-cymenol;2-p-cymenol;3-isopropyl-6-methyl-pheno
cas:	499-75-2
mf:	c10h14o
mw:	150.22
einecs:	207-889-6
product categories:	alcohols and derivatives;miscellaneous natural products
mol file:	499-75-2.mol

carvacrol chemical properties

melting point	3-4 °c(lit.)
boiling point	236-237 °c(lit.)
density	0.976 g/ml at 20 °c(lit.)
refractive index	n20/d 1.522(lit.)
fema	2245 \| carvacrol
fp	224 °f
storage temp.	20°c
solubility	1.25g/l
water solubility	insoluble
merck	14,1872
stability:	stable. combustible. incompatible with strong bases, strong oxidizing agents.
cas database reference	499-75-2(cas database reference)
nist chemistry reference	phenol, 2-methyl-5-(1-methylethyl)-(499-75-2)
epa substance registry system	phenol, 2-methyl-5-(1-methylethyl)- (499-75-2)

safety information

hazard codes	c
risk statements	22-34
safety statements	26-36/37/39-45
ridadr	un 3265 8/pg 3
wgk germany	3
rtecs	fi1225000
hazardclass	8
packinggroup	iii
hazardous substances data	499-75-2(hazardous substances data)

msds information

provider	language
acros	english
sigmaaldrich	english

carvacrol usage and synthesis

artificial flavor

carvacrol is the isomeric body of thymol with similar aroma as thymol. carvacrol naturally exists in thyme oil and other essential oils, having especially high content in the thyme oil produced in spain.
carvacrol is mainly used in the preparation of dill, girofle, mint and vanilla flavor to be used for toothpaste, toothpaste powder, oral products, talcum powder, soap and daily industrial products. in medicine, it is used for local anesthetics. in addition, carvacrol is capable of killing bacteria and intestinal parasites and can be used as disinfectants and fungicides. according to the information reported, the acute toxicity data of carvacrol: oral ld50810mg/kg (rat), skin test: ld50> 5g/kg (rabbit).
thyme plant has its origin including the northeast, hebei, and inner mongolia, gansu, qinghai and xinjiang and other provinces. ingredients: whole plant of thyme contains about 0.15~0.5% volatile oil (in oil, the component mainly contains carvacrol, paraffin, thymol), amaroid and tannin. leaves contain free oleanolic acid, ursolic acid, caffeic acid and so on. thyme can be not only used in medicine, for spices, but also be as the superior natural health ingredients of the processed foods. since the 1980s, thyme-like herbal foods have become very popular. studies have shown that thyme-containing volatile oils, in addition to being used as seasoning and for treatment of illnesses, also have anti-corrosion, antibacterial and other functions. therefore, the consumers can benefit a lot using it as food raw materials. because of this, in europe, natural herbal tea also contains thyme. for example, a kind of herb tea raw material having anti-cough effect and being able to prevent and treat bronchitis has 10% thyme leaves.

image 1: thymus plant

chemical properties

use sulfuric acid to sulfonate the p-isopropyl toluene, generating p-isopropyl toluene-2-sulfonic acid. then we can obtain carvacrol after alkali melting treatment.

image 2: preparation of carvacrol from p-isopropyltoluene
carvacrol, when co-melted together with potassium hydroxide, can give 2-hydroxy-4-isopropyl benzoic acid while reaction with phosphorus pentachloride can generate 2-chloro-1-methyl-4-isopropyl benzene. in acetic acid, it reaction with 1 mol bromine can generate 4-bromocarbinol while its reaction with 2 mol bromine can generate 4, 6-dibromo carvacrol; if reacted with bromine and aluminum, we can obtain tetrabromo-o-cresol. it is easily soluble in concentrated sulfuric acid to produce 2-methyl-5-isopropyl phenol-4-sulfonic acid. in aqueous sodium hydroxide solution, it can be reacted with formaldehyde to generate carvacrol phenols alcohol:

image 3: the reaction between carvacrol and formaldehyde for generation of carvacrol phenolic alcohol
it exhibits green color when reacted with ferric chloride in ethanol with no significant color in the water.

content analysis

it can be determined by the non-polar column method by gt-10-4.

toxicity

gras (fema).
ld50: 810 mg/kg (rat, oral).

toxicity

gras (fema).
ld50: 810 mg/kg (rat, oral).

usage limit

fema (mg/kg): soft drinks 26; cold drinks 34; candy 92; baked goods 120; condiments 37.
take appropriate as limit (fda § 172.515, 2000).
allow to use (gb 2760-1996).

standard for maximum allowable amount

name of additive	field allowed to use it as additive	function of additive	maximal allowable amount（g/kg）
arvacrol	food	food spices	the perfume ingredients used in formulating fragrances shall not exceed the maximum allowable documented amount in gb 2760

chemical properties

it appears as colorless to pale yellow slightly viscous oil. when placed in air and light, its color becomes darker. it has spicy, cool incense, herbs incense with thymol-like smell. it has a boiling point of 238 ° c, the melting point of 0.5 to 1 ° c and the flash point of 100 ° c. it is soluble ethanol, ethyl ether, propylene glycol and alkali, do not dissolve in water. it is miscible in oil.
the natural products are found in thyme oil (about 70%), oregano oil (about 80%) and mange to oil and so on.

application

spices; it is mainly used for the preparation of dill, girofle, meat, peppermint, vanilla flavor and so on.
it can be used for the preparation of spices, fungicides and disinfectants. as a spice, it can be used in toothpaste, soap and other daily necessities, but also for food flavors.
it can be used for spices, food additives, feed additives, antioxidants, sanitation fungicide, insect repellent, preservatives, deodorant and pharmaceutical intermediates.

preparation

it can be obtained through treatment of the essential oil containing rich content of natural carvacrol followed by ether extraction or steam distillation to derive it.
it can be derived by the sulfonation of thymol followed by alkali treatment.