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HENAN SUNLAKE ENTERPRISE CORPORATIONDasatinib//file1.lookchem.com/cas/reactions/2021/06/02/9966762.png
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Dasatinib CAS NO.302962-49-8

Min.Order Quantity:
1 Kilogram
Purity:
98%
Port:
TIANJIN/SHANGHAI
Payment Terms:
L/C,D/P,T/T,

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Product Details

Keywords

  • 5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-
  • BMS-354825
  • N-[2-Chloro-6-methylphenyl]-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide

Quick Details

  • ProName: Dasatinib
  • CasNo: 302962-49-8
  • Molecular Formula: C22H28ClN7O3S
  • Appearance: white solid
  • Application: Pharmaceutical intermediate
  • DeliveryTime: within 7-10days after receiving paymen...
  • PackAge: as required
  • Port: TIANJIN/SHANGHAI
  • ProductionCapacity: 100 Kilogram/Month
  • Purity: 98%
  • Storage: room temperature
  • Transportation: by sea/ by express
  • LimitNum: 1 Kilogram

Superiority

henan sunlake enterprise corporation

our advantages

1, any inquiry about chemicals will be welome and replied within 24 hours;

2, competitive price;

3, good quality is guaranteed;

4, fast and safe delivery;

5, full experience in manufacture and international trade;

6, perfect and professional service.

Details

product information

dasatinib basic information
leukemia drug chemical properties application
product name: dasatinib
synonyms: dasatinib(bms-354825);bms-354825;n-[2-chloro-6-methylphenyl]-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide;5-thiazolecarboxamide, n-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-;dasatinib;n-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide;n-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide;2-{6-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-2-methyl-pyrimidin-4-ylamino}-thiazole-5-carboxylic acid (2-chloro-6-methyl-phenyl)-amide
cas: 302962-49-8
mf: c22h28cln7o3s
mw: 488.01
einecs:
product categories: intermediates & fine chemicals;pharmaceuticals;tyrosine kinase inhibitors;pharmaceutical intermediate;inhibitor;sprycel;anti-cancer&immunity;inhibitors
mol file: 302962-49-8.mol
dasatinib structure
dasatinib chemical properties
mp 275-286°c
storage temp. -20°c freezer
cas database reference 302962-49-8(cas database reference)
safety information
msds information
dasatinib usage and synthesis
leukemia drug dasatinib is an oral potent oncogenic kinase inhibitor, which can block signal of cancer cell replication acceleration , in may 2009, the us food and drug administration (fda) formally approved the sale of dasatinib , it has been clinically used for the treatment of various chronic myeloid leukemia (cml), including treatment of chronic myeloid leukemia which is resistant or intolerant to the treating programs including imatinib mesylate., philadelphia chromosome-positive acute lymphoblastic leukemia (ph + all) and the treatment of patients with solid tumors.
october 28, 2010 ,the fda approved dasatinib (sprycel) of the new indication which is used for the treatment of the rare leukemia first diagnosed philadelphia chromosome-positive called chronic myeloid leukemia (ph + cp-cml) . the disease is a blood and bone marrow disease associated with genetic abnormality .
an open-label randomized clinical trial conducted in patients with cp-cml evaluated the safety and efficacy of dasatinib . common side effects include decreased activity of the bone marrow caused by red blood cells, white blood cells and platelets decreased (myelosuppression), fluid retention, diarrhea, headache, musculoskeletal pain, and rash.
october 11, 2011, the us food and drug administration (fda) said the leukemia drug dasatinib (sprycel, bristol-myers squibb company) might increase pulmonary arterial hypertension (pah) risk. pulmonary hypertension is a rare but serious disease that can lead to the condition that heart pumping blood to the lungs becomes more difficult by raising the pressure . pah symptoms include shortness of breath, fatigue, swelling of the legs and ankles, clinicians must differentiate these symptoms from other similar symptoms.
since 2006 dasatinib was approved in the us market ,there had been 12 associated pulmonary hypertension events ,pulmonary hypertension symptoms included shortness of breath, fatigue, hypoxia and fluid retention, patients then were confirmed pulmonary hypertension by the results of right heart catheterization ,studies have shown that the biggest cause of the disease may come from patients taking dasatinib.
the above information is edited by the chemicalbook of tian ye.
chemical properties white solid
application suitable for treatment of chronic myeloid leukemia which is resistant or intolerant to the treating programs including imatinib mesylate.
chemical properties pale-yellow solid
usage a new, oral, small-molecule tyrosine kinase inhibitor (tki) for the treatment of cml. antineoplastic
company information

henan sunlake enterprise corporation is located in henan province , the central plain of china , which enjoys favorable geogeaphical position and convenient transportion, the com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .

sunlake is a professional manufacturer engaged in producing and selling chemicals,including organic & inorganic chemicals , pigments & dyestuffs , water treatment chemicals , food & feed additives and others . these products have been being well exported to europe , southeast asia , the middle east , africa , south america and some other countries and areas.

we sincerely welcome foreign friends to visit our plant for cooperation. with the idea of "quality first,credit priority, excellent service", we are highly acknowledged by customers for good quality and competitive price. more importantly , the company has a strong r & d team, who are professional engineers and scholars with ph. d. .so we are confident to serve you better with our high - quality products and professional team.

we are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional wupplier in international market.

we welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate.

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