Diltiazem Hydrochloride CAS NO.33286-22-5

product name

diltiazem hcl

synonyms

diltiazem hydrochloride; (2s,3s)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate; (2s,3s)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate hydrochloride (1:1); dilthiazem hydrochloride

molecular formula

c₂₂h₂₇cln₂o₄s

molecular weight

450.9788

inchi

inchi=1/c22h26n2o4s.clh/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21h,13-14h2,1-4h3;1h/t20-,21+;/m1./s1

cas registry number

33286-22-5

einecs

251-443-3

molecular structure

melting point

210-215℃

boiling point

594.4°c at 760 mmhg

flash point

313.3°c

water solubility

soluble

vapour pressur

4.27e-14mmhg at 25°c

hazard symbols

xn:harmful;

risk codes

r22:;
r40:;

safety description

s36/37:;
s45:;

appearance

white or almost white, crystalline powder.

solubility

freely soluble in water, in methanol and in methylene chloride, slightly soluble in anhydrous ethanol.

mp

about 213 °c, with decomposition.

identification

ir

correspond with crs

thin-layer chromatography

correspond with working standard

c

correspond with working standard

d

gives reaction of chlorides

appearance of solution s

clear and colorless

ph

4.3 to 5.3

specific optical rotation

+115 to +120

related substances

total impurities

not more than 0.3%

disregard limit

0.025 times the area of the principal peak in the chromatogram obtained with reference solution

heavy metals

maximum 10ppm

loss on drying

maximum 0.5%

sulphated ash

maximum 0.1%

content

98.5 per cent to 101.0 per cent (dried substance).