Doxorubicin hydrochloride CAS NO.25316-40-9

Min.Order Quantity:: 1 Kilogram

Purity:: 99%

Port:: Any port of China

Payment Terms:: L/C,T/T,MoneyGram

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Product Details

Keywords

25316-40-9
Doxorubicin hydrochloride
C27H30ClNO11

Quick Details

ProName: Doxorubicin hydrochloride
CasNo: 25316-40-9
Molecular Formula: C27H30ClNO11
Appearance: conform
Application: intermediate
DeliveryTime: with 10 days after order confirmed
PackAge: as per buyers
Port: Any port of China
ProductionCapacity: 1 Metric Ton/Day
Purity: 99%
Storage: R.T.
Transportation: by air/sea
LimitNum: 1 Kilogram

Superiority

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4.customs synthesis

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Details

doxorubicin hydrochloride basic information

product name:	doxorubicin hydrochloride
synonyms:	adriacin;adriblastina;adriblastina hydrochloride;adriamycin hcl;adriamycin hydrochloride;(8s-cis)-10-[(3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride;14-hydroxydaunomycin hcl;14-hydroxydaunomycin hydrochloride
cas:	25316-40-9
mf:	c27h30clno11
mw:	579.98
einecs:	246-818-3
product categories:	apis;active pharmaceutical ingredients;api;intermediates & fine chemicals;pharmaceuticals;antitumour;adriamycin;inhibitor;anti-cancer&immunity;inhibitors
mol file:	25316-40-9.mol

doxorubicin hydrochloride chemical properties

mp	216 °c (dec.)(lit.)
storage temp.	2-8°c
solubility	h₂o: 10 mg/ml, clear, red-orange
merck	13,3473
cas database reference	25316-40-9(cas database reference)
epa substance registry system	5,12-naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-. alpha.-l-lyxo-hexopyranosyl) oxy]-7,8,9,10-tetrahydro- 6,8,11-trihydroxy-8-(hydroxyacetyl)- 1-methoxy-, hydrochloride, (8s,10s)-(25316-40-9)

safety information

hazard codes	t,t+,xi
risk statements	45-22-40-26/27/28-36/38
safety statements	53-45-36/37/39-22-7/9
wgk germany	3
rtecs	qi9295900
f	10-21

msds information

provider	language
(8s-cis)-10-[(3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride	english
sigmaaldrich	english

doxorubicin hydrochloride usage and synthesis

chemical properties	orange-red crystalline solid
usage	used as an antineoplastic
usage	strong fluorescent dye intercalating into dna. antitumour antibiotic. effect of adriamycin on heart mitochondrial dna. inhibitor of reverse transcriptase and rna polymerase; immunosuppressive agent.
usage	antibacterial;dna intercalant
usage	doxorubicin hydrochloride (adriamycin hydrochloride) is an antitumour agent that has been formulated as a salt to achieve higher water solubility. while the salt shares the same pharmacological properties as doxorubicin free base, its greater water solubility may offer advantages in some in vitro applications. physicochemical properties and chromatographic behaviour will depend on whether the ph is buffered. in non-ph controlled systems the free base and salt may behave differently.
usage	doxorubicin hydrochloride (adriamycin hydrochloride) is an antitumor agent that has been formulated as a salt to achieve higher water solubility. while the salt shares the same pharmacological properties as doxorubicin free base, its greater water solubility may offer advantages in some in vitro applications. physicochemical properties and chromatographic behaviour will depend on whether the ph is buffered. in non-ph controlled systems the free base and salt may behave differently.
general description	orange-red thin needles. aqueous solutions yellow-orange at acid phs, orange-red at neutral phs, and violet blue over ph 9.
air & water reactions	water soluble.
reactivity profile	amines, like doxorubicin hydrochloride, are weak chemical bases. they neutralize acids to form salts plus water. these acid-base reactions are exothermic. amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
fire hazard	doxorubicin hydrochloride is probably combustible.
biological activity	antitumor antibiotic agent that inhibits dna topoisomerase ii. dna intercalator that inhibits nucleic acid synthesis and induces apoptosis.