USD $27.50-33.00 / Gram
USD $1.00-10.00 / Kilogram
USD $10.00-10.00 / Gram
USD $9.00-99.00 / Kilogram
USD $9.00-99.00 / Kilogram
USD $9.00-99.00 / Kilogram
USD $9.00-99.00 / Kilogram
USD $1.00-20.00 / Gram
the fluocinolide with cas registry number of 356-12-7 is also known as topsymin. the systematic name is 2-[(4as,4br,5s,6as,6bs,9ar,10as,10bs,12s)-4b,12-difluoro-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bh-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl]-2-ox oethyl acetate. it belongs to product categories of steroids. its einecs registry number is 206-597-6 . in addition, the formula is c26h32f2o7 and the molecular weight is 494.52. this chemical is a white crystalline powder and used for atopic dermatitis, eczema and so on.
physical properties about fluocinolide are:
(1)acd/logp: 3.36;
(2)# of rule of 5 violations: 0;
(3)acd/logd (ph 5.5): 3.36;
(4)acd/logd (ph 7.4): 3.36;
(5)acd/bcf (ph 5.5): 209.69;
(6)acd/bcf (ph 7.4): 209.69;
(7)acd/koc (ph 5.5): 1597.31;
(8)acd/koc (ph 7.4): 1597.3;
(9)#h bond acceptors: 7;
(10)#h bond donors: 1;
(11)#freely rotating bonds: 5;
(12)index of refraction: 1.56;
(13)molar refractivity: 119.09 cm3;
(14)molar volume: 368 cm3;
(15)surface tension: 49.9 dyne/cm;
(16)density: 1.34 g/cm3;
(17)flash point: 311.3 °c;
(18)enthalpy of vaporization: 101.2 kj/mol;
(19)boiling point: 591.1 °c at 760 mmhg;
(20)vapour pressure: 1.97e-16 mmhg at 25 °c.
preparation of fluocinolide: it is prepared by reaction of acetic acid anhydride with fluocinolon-acetonid. the reaction needs reagent trimethylsilyl trifluoromethanesulfonate and solvent ch2cl2 at the temperature of 20 °c for 5 minutes. the yield is about 100%.