GHRP-6 Pralmorelin 5mg 10mg CAS NO.87616-84-0

molecular formula: c46h56n12o6
molar mass: 873.014
cas number: 87616-84-0
pubchem: 5486806
synonyms: growth hormone releasing peptide-6; ghrp6; ghrp 6

ghrp-6 is a potent stimulator of natural growth hormone release. ghrp-6 is a hexa-peptide that promotes food intake by stimulating hunger and helps increase energy metabolism. growth hormone releasing peptides, similar to ghrp-6, are most commonly used for treatment of growth hormone (gh) deficiencies, eating disorders, obesity, etc. research has shown that use of these hgh peptides increases lean muscle mass, strength, stamina and decreases body fat.

the development of ghrp-6
in 1982, the natural hormone "growth hormone releasing hormone" (ghrh) was identified after a prolonged search. soon, researchers discovered that those gh-releasing peptides (specifically ghrp-6 & ghrp-2) followed a mode of action which bound them to and was mediated through receptors different from those for ghrh. furthermore, researches discovered that these gh-releasing peptides acted synergistically with the natural hormone growth hormone releasing hormone (ghrh), which is related to sermorelin, in both laboratory animals and humans to produce large releases of growth hormone. in the 1980s, the first highly potent gh-releasing peptide, ghrp-6, was developed. due to a strong gh release response from the the peptide, it became the first member of a class called growth hormone secretagogues. ghrp-6 is a hexapeptide composed of 6 amino acids: l-histidine, d-tryptophan, l-alanine, l-tryptophan, d-phenylalanine and l-lysine. the "l" form of an amino acid is the naturally occurring form and often in the nomenclature the "l" is dropped. the "d" form does not occur in nature and is the isomeric form (i.e. mirror image) of the naturally occurring "l" form. ghrp-6 (his-d-trp-ala-trp-d-phe-lys-nh2) is composed of both natural and isomeric forms of those 6 amino acids.this sequence provides a signal to the body to begin secreting growth hormone release while also blocking somatostatin, a hormone that inhibits the release of growth hormone.

studies related to the ghrp-6 peptide
investigations reported that ghrp-6 is more efficient than ghrh itself in monkeys and performs synergistically when combined or applied together. an example of this combination would be ghrp-2 and cjc-1295. ghrp-6 is believed to be acting naturally on both pituitary and hypothalamic sites (fairhall et al. 1995). in a time-dependent and dose-dependent manner, the primary pituitary cells of rats were demonstrated on. from the studies, the concentrations of the ghrp-6 needed for the half-maximal and maximal stimulation were 7 x 10(-9) and 10(-7) m, respectively.