Genistein 446-72-0 Large in promotion CAS NO.446-72-0

genistein chemical properties

mp 297-298 °c
storage temp. −20°c

solubility dmso: soluble

form powder

color off-white

water solubility insoluble
merck 14,4391
brn 263823
stability: light sensitive
cas database reference 446-72-0(cas database reference)
epa substance registry system 4h-1-benzopyran- 4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)- (446-72-0)

safety information

hazard codes xi
risk statements 36/38
safety statements 26-24/25-22
wgk germany 3

rtecs nr2392000

hazardclass irritant
hazardous substances data 446-72-0(hazardous substances data)

genistein usage and synthesis

chemical properties yellow crystalline solid
usage exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (ic50 - 2.6um). also inhibits other protein kinases through competitive inhibition of atp. inhibits tumor cell proliferation and induces tumor cell differentiation. produces cell-cycle arrest and apoptosis in jurat t-leukemia cells. however, it prevents anti-cd3 monoclonal antibody-induced thymic apoptosis. genistein also inhibits topoisomerase ii activity in vitro. genistein has also been shown to inhibit the action of gaba on recombinant gabaa receptors 2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol
usage genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (ptk) which blocks the mitogenic effect mediated by egf on nih-3t3 cells with ic50 of 12μm or by insulin with ic50 of 19 μm.
usage cytotoxic inhibitor of tyrosine kinase and topoisomerase ii kinase
biological activity phytoestrogen with a wide range of biological actions. inhibits protein tyrosine kinases including epidermal growth factor receptor kinase. also binds to ppar γ and estrogen receptors and acts as an agonist at gpr30. also available as part of the mapk cascade inhibitor tocriset™ .

genistein preparation products and raw materials

raw materials diethyl ether