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Chemical Co.LtdHigh Quality SAMe S-Adenosyl-L-Methionine / 29908-03-0//file1.lookchem.com/300w/synthetic/2022-01-22-09/3a60a2e7-71c3-45e3-9cb7-904bce592c33.png

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High Quality SAMe S-Adenosyl-L-Methionine / 29908-03-0 CAS NO.29908-03-0

FOB Price:
USD 1.00-1.00 /Metric Ton Get Latest Price
Min.Order Quantity:
1 Metric Ton
Purity:
99%min
Port:
Shanghai port
Payment Terms:
L/C,D/A,D/P,T/T,MoneyGram,Other

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Product Details

Keywords

  • High Quality SAMe S-Adenosyl-L-Methionine / 29908-03-0
  • SAMe S-Adenosyl-L-Methionine
  • CAS 29908-03-0

Quick Details

  • ProName: High Quality SAMe S-Adenosyl-L-Methion...
  • CasNo: 29908-03-0
  • Molecular Formula: C15H24N6O5S
  • Appearance: WhitePowder
  • Application: pharmaceutical intermediates
  • DeliveryTime: within 5-7 days after payment
  • PackAge: 25kg/ drum, or as your requirements
  • Port: Shanghai port
  • ProductionCapacity: 100 Metric Ton/Month
  • Purity: 99%min
  • Storage: regualr storage
  • Transportation: By air、ship and courier
  • LimitNum: 1 Metric Ton
  • Related Substances: undetected
  • Residue on Ignition: less than 0.05%
  • Heavy Metal: less than 0.02%
  • Valid Period: 3 years
  • EINECS: 249-946-8
  • Application: Pharm Intermediates
  • Appearance: WhitePowder
  • Molecular Weight: 400.45
  • Melting point: 202-204°C
  • Brand: zhishang
  • Product name: S-Adenosyl-L-methionine
  • HPLC: available
  • NMR: available

Superiority

1.professional manufacturer
2.best price
3.fast delivery
4.prompt before and after sale service
5.quality guarantee
6.reliable and truthworthy supplier

Details

high quality s-adenosyl-l-methionine, s-adenosyl methionine, 29908-03-0, c15h24n6o5s gmp manufacturers

s-adenosyl methionine same 29908-03-0 same99%

same (s-adenosyl-l-methionine)

cas no. 29908-03-0

purity: 98% 99%

coa of specification

total content

≥98%

ademetionine

50.0~53.0%

identification

chemical reaction

positive

ir

conforms

retention time of a major peak

meet the requirements

clarity of solution

≤reference solution y1

acid value

1.5~2.5

sadenosyl-l-homocystein (hplc)

≤0.5

methithioadenosine(hplc)

≤1.0%

adenine(hplc)

≤0.5%

s.s isomer(hplc)

≥62.0%

butanedisufoinc acid

46.0~49.0%

endotoxin

≤0.3eu/mg

water content

≤3.0%

residue on ignition

≤0.3%

heavy metals

≤10ppm

appearance

almost white powder, very hygroscopic

function:

1 s-adenosyl methionine (sam, same, sam-e) is a coenzyme involved in methyl group transfers. it is made from adenosine triphosphate (atp) and methionine by methionine adenosyltransferase (ec 2.5.1.6). transmethylation, transsulfuration, and aminopropylation are the metabolic pathways that use sam. although these anabolic reactions occur throughout the body, most sam is produced and consumed in the liver.

2 the methyl group (ch3) attached to the methionine sulfur atom in sam is chemically reactive. this allows donation of this group to an acceptor substrate in transmethylation reactions. more than 40 metabolic reactions involve the transfer of a methyl group from sam to various substrates such as nucleic acids, proteins, and lipids.
3 in bacteria, sam is bound by the sam riboswitch, which regulates genes involved in methionine or cysteine biosynthesis.
the reactions that produce, consume, and regenerate sam are called the sam cycle. in the first step of this cycle, the sam-dependent methylases (ec 2.1.1) that use sam as a substrate produce s-adenosyl homocysteine as a product.this is hydrolysed to homocysteine and adenosine by s-adenosylhomocysteine hydrolase ec 3.3.1.1 and the homocysteine recycled back to methionine through transfer of a methyl group from 5-methyltetrahydrofolate, by one of the two classes of methionine synthases (ec 2.1.1.13 or ec 2.1.1.14). this methionine can then be converted back to sam, completing the cycle.
4 another major role of sam is in polyamine biosynthesis. here, sam is decarboxylated by adenosylmethionine decarboxylase (ec 4.1.1.50) to form s-adenosyl-5'-3-methylpropylamine. this compound then donates its n-propylamine group in the biosynthesis of polyamines such as spermidine and spermine from putrescine.
5 sam is required for cellular growth and repair. it is also involved in the biosynthesis of several hormones and neurotransmitters that affect mood, such as dopamine and serotonin. methyltransferases are also responsible for the addition of methyl groups to the 2' hydroxyls of the first and second nucleotides next to the 5' cap in messenger rna.
6 in the united states, sam is sold as a nutritional supplement under the marketing name sam-e (also spelled same or same). some research has indicated that taking sam on a regular basis help fight depression, liver disease, and the pain of osteoarthritis. multiple clinical trials indicate benefits for depression, some liver conditions and osteoarthritis. all other indications are not yet proven.


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