Indometacin CAS NO.53-86-1

Min.Order Quantity:: 50 Gram

Purity:: 97%

Port:: Shanghai Port

Payment Terms:: L/C,D/A,D/P,T/T,MoneyGram,Other

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Keywords

INDOCIN
53-86-1 supplier
53-86-1 price

Quick Details

ProName: Indometacin
CasNo: 53-86-1
Molecular Formula: C19H16ClNO4
Appearance: Crystalline Solid
Application: additives
DeliveryTime: 7-10 working days
PackAge: Fluoride barrel
Port: Shanghai Port
ProductionCapacity: 200 Kilogram/Month
Purity: 97%
Storage: Protected from light, stored hermetica...
Transportation: By air or courier or sea
LimitNum: 50 Gram
Molecular Weight: 357.79

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henan sunlake enterprise corporation

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indometacin basic information

anti-inflammatory analgesic pharmacokinetics usage and dosage adverse reactions matters need attention chemical property application methods of production category classification of toxicity acute toxicity combustible hazard characteristics storage and transportation characteristics extinguisher

product name:	indometacin
synonyms:	aurora ka-6542;indocin;indometacin;indometacine;indomethacin;indomethacine;labotest-bb lt00244830;1-(p-chlorobenzyl)-5-methoxy-2-methylindole-3-acetic acid
cas:	53-86-1
mf:	c19h16clno4
mw:	357.79
einecs:	200-186-5
product categories:	pharmaceuticals;active pharmaceutical ingredients;all inhibitors;inhibitors;intermediates & fine chemicals;lipid signaling;indocin;other apis;pharmaceutical raw chemicals
mol file:	53-86-1.mol

indometacin chemical properties

mp	155-162 °c
storage temp.	store at rt
solubility	ethanol: 50 mg/ml, clear, yellow-green
merck	4968
stability:	stable. incompatible with strong oxidizing agents.
cas database reference	53-86-1(cas database reference)
nist chemistry reference	indomethacin(53-86-1)
epa substance registry system	1h-indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy- 2-methyl-(53-86-1)

safety information

hazard codes	t+,xi,t
risk statements	28-36/37/38-39/23/24/25-23/24/25
safety statements	28-36/37-45-36-26
ridadr	un 2811 6.1/pg 1
wgk germany	3
rtecs	nl3500000
f	8-10
hazardclass	6.1
packinggroup	i
hazardous substances data	53-86-1(hazardous substances data)

msds information

provider	language
1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1h-indole-3-acetic acid	english
sigmaaldrich	english
alfa	english

indometacin usage and synthesis

anti-inflammatory analgesic	indomethacin is a kind of stronger corticoid anti-inflammatory and antipyretic and analgesic, by inhibiting cyclooxygenase reducing the synthesis of prostaglandin (pg), to prevent the formation of the nere impulses, inflammation tissue inhibiting inflammatory reaction, including inhibition of leukocyte chemotaxis and lysosomal enzyme release, etc., and produce antipyretic, analgesic and anti-inflammatory effects. indomethacin anti-inflammatory, antipyretic effect is very strong, its anti-inflammatory effect is better than bute, 84 times better than hydrocortisone, and sugar cortical hormone, used in combination with aspirin, bute, can reduce their dosage, toxic and side effects, improve curative effect; second is antipyretic effect, 10 times than amidopyrine ;its analgesic action is weak , only to the inflammatory pain has obvious analgesic effect, but the effect is good for inflammatory pain than baotai loose, analgin and salicylic acid. clinical is mainly used for the salicylic acid, drugs are less tolerance or curative effect is not obvious in the acute and chronic rheumatic or rheumatoid arthritis, ankylosing spondylitis, slippery bursa phlogistic, tenosynovitis, articular capsulitis, osteoarthritis and acute gout and cancerous pain, etc.in recent years, the researchers try to use indomethacin biliary colic, dysmenorrhea, migraine, glomerulonephritis, polyuria, salmonella gastroenteritis, orthostatic hypotension, bart syndrome and so on, all have good curative effect.it can also be used to treat eye pigment meningitis, keratitis, scleritis, glaucoma and fever caused by cancer or other difficult to control the fever. dermatologist for lupus erythematosus (sle), white plug syndrome, scleroderma, nodular erythema, herpes zoster, joint type of psoriasis, etc. photosensitive dermatitis induced by topical treatment of eczema, allergic dermatitis, and local pain.
pharmacokinetics	oral medicine absorbed quickly and completely, can absorb more than 90% of the dosage of food with in 4 h, take medicine of acid containing aluminum and magnesium can be slightly slowed absorption, plasma protein conjugation rate is about 99%. after oral 25 mg, tmax is 1 ~ 4 h, the blood medicine peak concentration (cmax) is 1.4 mu g/ml, when 50 mg, cmax is 2.8 mu g/ml; half-life (t1/2) of an average is 4.5 h, premature extended obviously. a small amount of indomethacin can through the blood-brain barrier. and through the placenta.this article in the liver metabolism go methyl chloride and chlorobenzene formyl chloride, and can be hydrolyzed into recycle indomethacin to absorb. renal excretion from 60%, 10% ~ 20% in prototype discharge; part with droppings.33% from the bile excretion, 1.5% were prototype;in the breast milk also has a discharge (up to 0.5 ~ 2.0 mg daily).this product can not be dialysis to remove.
usage and dosage	1.anti-rheumatism: adult dosage: oral: early quantity from 25 to 50 mg each time, 2 ~ 4 times a day, immediately take at food service or after a meal. such as good tolerance, the daily dosage can be increased from 25 to 50 mg per week, the most mount should not be more than 200 mg a day. arthritis patients such as persistent pain at night or morning stiffness, can give quantity of 100 mg in bed all day. 2. resistance to gout: oral: at the beginning quantity is 100 mg once, then 50 mg, three times a day, until the pain relief, and then gradually reduced as soon as possible, until the drug withdrawal. 3. antifebrile: adult dosage: oral: 25 ~ 50 mg each time, 3 ~ 4 times daily.rectal drug delivery: every time 50 mg, 50 to 100 mg per day. pediatric dosage: oral: 0.5 ~ 1 mg/kg each time, 3 times a day. the above information is chemicalbook hanya edited.
adverse reactions	adverse reactions of indomethacin are high incidence , common adverse reactions are as follows: 1. nausea, vomiting, abdominal pain, diarrhea, anorexia, serious ulcers can occur and cause bleeding and perforation. after dinner, that can reduce the incidence. 2. common headache, dizziness, fatigue, occasional seizures, mental derangement, syncope, etc. should be paid attention to in due course. 3.the skin pruritus, erythema, urticaria, and one of the few of asthma, breathing problems and even breathing, circulation inhibition. 4.inhibition of hematopoietic system such as granulocytopenia, aplastic anemia, thrombocytopenia, and so on. although rare, but more severe consequences.there are also some other similar to aspirin reaction, notes are also the same.
matters need attention	1.indomethacin and aspirin have cross allergic. caused by aspirin allergic asthmatic patients, the application of this product can be induced bronchospasm. other non steroidal anti-inflammatory drugs to which are allergic may also be allergic to this product. 2.this product is contraindicated with active ulcer disease, ulcerative colitis and history, epilepsy, parkinson's disease, mental disease, liver and kidney function, the goods or aspirin or other nonsteroidal anti-inflammatory drug allergic person, angioedema or bronchial asthma. this product for the last 3 months of pregnancy can make fetal ductus arteriosus closure and result in persistent pulmonary hypertension, so pregnant women, disabled. this product can be discharged from the milk, breast-feeding women also disable. 3.this product is used for patients with cardiac insufficiency, and hypertension (because this product sodium can lead to water retention, hemophilia and other patients with hemorrhagic disease (because this product can make the bleeding time prolonged, aggravate bleeding tendency), aplastic anemia, granulocytopenia disease patients (this product is inhibition of hematopoietic system).age < 14 years old children should not be commonly used drug, when it is applied，it should be closely observed.easily occur in elderly patients with renal toxicity, which should also be careful. 4.because indomethacin has inhibition to the platelet aggregation, which can make the bleeding time prolonged, the role after the drug was stopped sustainable. during the blood urea nitrogen and serum creatinine，levels are also often higher. during the medication，it should be regularly check routine blood and liver and kidney function. case reports referred to in this article that the product can lead to corneal composure and retinal change (including macular degeneration), if it comes to the blurred vision eye exams should be done immediately. 5.drug overdose (especially when dose > 150 mg a day) is easy to cause toxic reactions such as nausea, vomiting, tension headaches, sleepiness, spirit, behavior disorders, etc., with vomiting or gastric lavage, symptomatic and supportive treatment.
chemical property	white or slightly yellow crystalline powder. melting point is 158-162℃, soluble in acetone, slightly soluble in ethanol, chloroform, ether, almost insoluble in water.
application	1.the product is anti-inflammatory, and antipyretic effect is obvious, mainly is used for salicylates to tolerance or the effect is not significant rheumatism and arthritis, ankylosing light spondylitis, osteoarthritis. 2.non steroid anti-inflammatory analgesic
methods of production	para aminophenylmethylether is through diazotization, reduction, cyclization, hydrolysis, acidification to get indomethacin.
category	poisonous
classification of toxicity	highly toxic.
acute toxicity	oral administration: ld50 2.42 mg / kg in rats; oral administration of 11.84 mg / kg of ld50: in mice.
combustible hazard characteristics	open flame fuel; high heat decomposition of toxic chloride and nitrogen oxide gas.
storage and transportation characteristics	low temperature and dry air ventilation; and oxidant, food additives separately.
chemical properties	crystalline solid
usage	inhibits cyclooxygenase (ic50=0.1um) selectively over liposygenases (ic50=100um for 5-,12- and 15-lo). a clinically useful naisd
usage	antiinflammatory, antipyretic, analgesic
extinguisher	foam, fog water, sand, carbon dioxide.
general description	crystals.
air & water reactions	practically insoluble in water. decomposes in alkali.
reactivity profile	a weak organic acid.
fire hazard	non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). contact with metals may evolve flammable hydrogen gas. containers may explode when heated.
biological activity	cyclooxgenase (cox) inhibitor; displays selectivity for cox-1 (ic 50 values are 230 and 630 nm for human cox-1 and cox-2 respectively). widely used anti-inflammatory agent.