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SHANGHAI SYSTEAM BIOCHEM CO., LTDPLX4032//file1.lookchem.com/300w/synthetic/2022-02-06-08/cb6ce5de-4e5c-4a2e-97ac-55e8dc12ff84.png
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PLX4032 CAS NO.918504-65-1

FOB Price:
USD 1.00-1.00 /Gram Get Latest Price
Min.Order Quantity:
100 Gram
Purity:
98%
Port:
shang hai
Payment Terms:
L/C

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Product Details

Keywords

  • PLX4032
  • N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaMide;PLX4032 (VeMurafenib);R7204;N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine-3-carbonyl)-2,4-d
  • 918504-65-1

Quick Details

  • ProName: PLX4032
  • CasNo: 918504-65-1
  • Molecular Formula: C23H18ClF2N3O3S
  • Appearance: white powder
  • Application: CAS:918504-65-1; N-(3-(5-(4-Chlorophe...
  • DeliveryTime: 3 months
  • PackAge: 100g,500,1kg.....
  • Port: shang hai
  • ProductionCapacity: 1000 Gram/Month
  • Purity: 98%
  • Storage: refrigerate
  • Transportation: shipping
  • LimitNum: 100 Gram

Superiority

we are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research.

we are committed to provide excellence in researching, manufacturing and drug discovery process.

our research team of scientists consists of western-trained ph.d.s with experience and capabilities in drug r&d methodologies and medicinal chemistry.

Details

vemurafenib (plx4032, rg7204; ro5185426) is a novel and potent inhibitor of b-rafv600e with ic50 of 31 nm.
ic50 value: 31 nm(b-rafv600e); 48 nm (c-raf )[1]
target: b-rafv600e
target: plx4032 inhibits b-rafv600e, c-raf, as well as wildtype b-raf, with ic50 of 31 nm, 48 nm and 100 nm, respectively. plx4032 also inhibits several non-raf kinases, including ack1, khs1, and srms, with ic50 of 18 nm to 51 nm [1]. in melanoma cell lines, the inhibitory effect by plx4032 depends on b-raf mutational status, because plx4032 potently inhibits those harboring b-raf v600 mutants, including v600e, v600d, v600k, and v600r, but not wildtype or other mutants. the ic50 values of plx4032 on these cells, including malme-3m, colo829, colo38, a375, sk-mel28, and a2058, ranges from 20 nm to 1 μm. in these cells, plx4032 (0.1 μm to 30 μm) also inhibits the phosphorylation of both mek1/2 and erk1/2 [2]. plx4032 is highly effective in the treatment of melanoma, for its ability of inhibiting b-rafv600e. however, plx4032 displays limited effect in colon cancer patients that also carrying b-rafv600e oncoprotein. the reason for this is that, in colon cancer cells, b-rafv600e inhibition by plx4032 results in a rapid feedback egfr activation, which compensates for the plx4032-inhibited cell proliferation [3].
in vivo: in b-rafv600e-mutant mice xenograft models, plx4032 (6 mg/kg–20 mg/kg) inhibits tumor growth [1]. in mice xenograft models of lox, colo829, and a375 cells, plx4032 (12.5 mg/kg–100 mg/kg) inhibits tumor growth and prolongs mice survival [2].

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