Pharmaceutical Ingredients Reserpine CAS 50-55-5 Treating High Blood Pressure Hypertension CAS NO.50-55-5

factory supply active pharmaceutical ingredients reserpine cas 50-55-5 treating high blood pressure hypertension

• quick detail of active pharmaceutical ingredients reserpine :

product name: reserpine

synonyms:

reserpine;3,4,5-trimethoxybenzoyl methyl reserpate;11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acid methyl ester;methyl reserpate;methyl reserpate 3,4,5-trimethoxybenzoic acid ester;l -carpserp;(3beta,16beta,17alpha,18beta,20alpha)-methyleste;,methylester,(3beta,16beta,17alpha,18beta,20alpha)-;

cas: 50-55-5;

einecs: 200-047-9;

mf: c33h40n2o9;

mw: 608.68.

• description of active pharmaceutical ingredients reserpine :

reserpine is an indole alkaloid, antipsychotic, andantihypertensive drug that has been used for the control of high blood pressure and for the relief of psychotic symptoms, although because of the development of better drugs for these purposes and because of its numerous side-effects, it is rarely used today.

the antihypertensive actions of reserpine are a result of its ability to deplete catecholamines (among other monoamine neurotransmitters) from peripheral sympathetic nerve endings. these substances are normally involved in controlling heart rate, force of cardiac contraction and peripheral vascular resistance.

• medical usage of active pharmaceutical ingredients reserpine:

medical:

reserpine is one of the few antihypertensive medications that have been shown in randomized controlled trials to reduce mortality: the hypertension detection and follow-up program, the veterans administration cooperative study group in anti-hypertensive agents, and the systolic hypertension in the elderly program.

reserpine is used with or without other medications to treat high blood pressure(hypertension). lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. it works by decreasing certain substances in the body (such as norepinephrine). this causes the blood vessels to relax so that blood can flow more easily and also slows the heart rate. these effects help to lower blood pressure.

reserpine is rarely used in the management of hypertension today. reserpine is a second-line adjunct agent for patients who are uncontrolled on a diuretic when cost is an issue.

it is also used to treat symptoms of dyskinesia in patients suffering from huntington's disease.

in some countries reserpine is still available as part of combination drugs for the treatment of hypertension, in most cases they contain also a diuretic and/or a vasodilator like hydralazine. these combinations are currently regarded as second choice drugs.

veterinary and other:

reserpine may be used as a sedative for horses.

another frequent use of reserpine is in the field of mass spectrometry where it is widely used as a reference standard owing to its availability, ease of ionization under electrospray conditions and stability in solution.

reserpine is used as a long-acting tranquilizer to subdue excitable or difficult horses and has been used illicitly for the sedation of show horses, for-sale horses, and in other circumstances where a "quieter" horse might be desired.

• technical testing sheet:

• dosage of active pharmaceutical ingredients reserpine:

the daily dose of reserpine in antihypertensive treatment is as low as 0.1 to 0.25 mg. the use of reserpine as an antipsychotic drug had been nearly completely abandoned, but more recently it made a comeback as adjunctive treatment, in combination with other antipsychotics, so that more refractory patients get dopamine blockade from the other antipsychotic, and dopamine depletion from reserpine.

doses for this kind of adjunctive goal can be kept low, resulting in better tolerability. originally, doses of 0.5 mg to 40 mg daily were used to treat psychotic diseases. doses in excess of 3 mg daily often required use of an anticholinergic drug to combat excessive cholinergic activity in many parts of the body as well as parkinsonism. for adjunctive treatment, doses are typically kept at or below 0.25 mg twice a day.

advantages:

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